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Association Between Plasmodium Infection and Blood Count Values: Implications for Malaria Diagnosis in Resource-Limited Settings.
Acta Parasitol
January 2025
Department of Biomedicine and Biotechnology, Faculty of Medicine, University of Alcala, Alcala de Henares, Spain.
Purpose: Malaria remains a major global health challenge, particularly in sub-Saharan Africa and low- and middle-income countries (LMICs), contributing substantially to mortality and morbidity rates. In resource-limited settings, access to specialized diagnostic tests is often restricted, making basic blood analysis a valuable diagnostic tool. This study investigated the correlation between malaria infection and full blood count values in a rural region of Ghana during the 2022 rainy season, aiming to highlight diagnostic insights available from routine blood analyses.
View Article and Find Full Text PDFCellular senescence induced by down-regulation of correlates with exon skipping of mitochondrial-related gene .
Life Med
April 2024
Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, School of Life Sciences, Fudan University, Shanghai 200438, China.
As the most prevalent type of alternative splicing in animal cells, exon skipping plays an important role in expanding the diversity of transcriptome and proteome, thereby participating in the regulation of diverse physiological and pathological processes such as development, aging, and cancer. Cellular senescence serving as an anti-cancer mechanism could also contribute to individual aging. Although the dynamic changes of exon skipping during cellular senescence were revealed, its biological consequence and upstream regulator remain poorly understood.
View Article and Find Full Text PDFPolypharmacy Associated With the Simultaneous Prevalence of Dry Eye Due to Aqueous Deficiency and Hyposalivation in Adults Over 50 Years Old.
Cureus
December 2024
Graduate Studies and Research Division at the Faculty of Dentistry, National Autonomous University of Mexico, Mexico City, MEX.
Introduction Dry eye and hyposalivation, often linked to Sjögren's syndrome (SS), are prevalent among adults. However, systemic diseases and their associated medications also play a role, as drug interactions can intensify the effects of certain medications. Objective To assess whether polypharmacy is associated with the co-occurrence of aqueous-deficient dry eye (ADDE) and hyposalivation in adults aged 50 years and older without SS.
View Article and Find Full Text PDFPreclinical evaluation and preliminary clinical study of Ga-NODAGA-NM-01 for PET imaging of PD-L1 expression.
Cancer Imaging
January 2025
Department of Nuclear Medicine, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Hongkou District, No. 100, Haining Road, Shanghai, 200080, China.
Background: Programmed cell death 1/programmed death ligand-1 (PD-L1)-based immune checkpoint blockade is an effective treatment approach for non-small-cell lung cancer (NSCLC). However, immunohistochemistry does not accurately or dynamically reflect PD-L1 expression owing to its spatiotemporal heterogeneity. Herein, we assessed the feasibility of using a Ga-labeled anti-PD-L1 nanobody, Ga-NODAGA-NM-01, for PET imaging of PD-L1.
View Article and Find Full Text PDFPsychometric properties of an arabic translation of the short boredom proneness scale (SBPS) in adults.
BMC Psychol
January 2025
School of Arts and Sciences, Department of Psychology and Education, Lebanese American University, Jbeil, Lebanon.
Background: The Short Boredom Proneness Scale (SBPS) is a common tool for assessing individuals' inclination toward Boredom. The Arabic version of the SBPS has not been validated despite the language being spoken by over 420 million people worldwide. Therefore, this study aims to translate the SBPS into Arabic and prove its psychometric properties on a sample of Arabic-speaking adults from Lebanon.
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