AI Article Synopsis
- Targeted drug delivery to glioblastoma (GBM) remains difficult due to the blood-brain barrier (BBB), but multifunctional exosome-mimetics (EM) have shown promise.
- The study introduces DTX@Ang-EM, which utilizes angiopep-2 to enhance drug delivery by reducing the formation of a protein corona and improving BBB penetration.
- Results indicate that DTX@Ang-EM effectively increases chemotherapy concentration in the tumor, inhibits GBM growth significantly, and minimizes side effects, suggesting a new approach for treating brain tumors.
Article Abstract
Targeted drug delivery to the glioblastoma (GBM) overcoming blood-brain barrier (BBB) has been challenging. Exosomes are promising vehicles for brain tumor drug delivery, but the production and purification hinder its application for nanomedicine. Besides, the formation of protein corona (PC) may affect the behaviour of nanocarriers. Here, multifunctional exosomes-mimetics (EM) are developed and decorated with angiopep-2 (Ang) for enhancing GBM drug delivery by manipulating PC. Docetaxel (DTX)-loaded EM with Ang modification (DTX@Ang-EM) show less absorption of serum proteins and phagocytosis by macrophages. Ang-EM show enhanced BBB penetration ability and targeting ability to the GBM. Ang-EM-mediated delivery increase the concentration of DTX in the tumor area. The multifunctional DTX@Ang-EM exhibits significant inhibition effects on orthotopic GBM growth with reduced side effects of the chemotherapeutic. Findings from this study indicate that the developed DTX@Ang-EM provide a new strategy for targeted brain drug delivery and GBM therapy.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647369 | PMC |
| http://dx.doi.org/10.1186/s12951-021-01153-3 | DOI Listing |
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