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Associations between accelerated forgetting, amyloid deposition and brain atrophy in older adults.
Brain
October 2024
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1N 3AR, UK.
Article Synopsis
- Accelerated long-term forgetting (ALF) describes a situation where information is remembered well in the short term but forgotten quickly over longer periods, and it could be an early sign of cognitive decline, possibly related to Alzheimer's disease.
- In a study involving 429 participants aged about 73, researchers assessed ALF using visual and verbal memory tests and looked at the impact of brain pathology on memory retention and forgetting.
- Results showed that people with amyloid plaques (linked to Alzheimer's) forgot details of a complex figure more quickly than those without, and overall retention was higher for the 'outline' of the figure compared to 'detail' items.
Verbal Learning and Memory Deficits across Neurological and Neuropsychiatric Disorders: Insights from an ENIGMA Mega Analysis.
Brain Sci
June 2024
Department of Neurology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Deficits in memory performance have been linked to a wide range of neurological and neuropsychiatric conditions. While many studies have assessed the memory impacts of individual conditions, this study considers a broader perspective by evaluating how memory recall is differentially associated with nine common neuropsychiatric conditions using data drawn from 55 international studies, aggregating 15,883 unique participants aged 15-90. The effects of dementia, mild cognitive impairment, Parkinson's disease, traumatic brain injury, stroke, depression, attention-deficit/hyperactivity disorder (ADHD), schizophrenia, and bipolar disorder on immediate, short-, and long-delay verbal learning and memory (VLM) scores were estimated relative to matched healthy individuals.
View Article and Find Full Text PDFAssociations Between Midlife Anticholinergic Medication Use and Subsequent Cognitive Decline: A British Birth Cohort Study.
Drugs Aging
June 2024
MRC Unit for Lifelong Health and Ageing at UCL, London, UK.
Background: Anticholinergic medication use is associated with cognitive decline and incident dementia. Our study, a prospective birth cohort analysis, aimed to determine if repeated exposure to anticholinergic medications was associated with greater decline, and whether decline was reversed with medication reduction.
Methods: From the Medical Research Council (MRC) National Survey of Health and Development, a British birth cohort with all participants born in a single week of March 1946, we quantified anticholinergic exposure between ages 53 and 69 years using the Anticholinergic Cognitive Burden Scale (ACBS).
Accuracy of energy and nutrient intake estimation versus observed intake using 4 technology-assisted dietary assessment methods: a randomized crossover feeding study.
Am J Clin Nutr
July 2024
Curtin School of Population Health, Curtin University, Kent Street, GPO Box U1987, Perth 6845, WA, Australia; Curtin Health Innovation Research Institute, Curtin University, Kent Street, GPO Box U1987, Perth 6845, Australia. Electronic address:
Article Synopsis
- A study was conducted to evaluate the accuracy of four technology-assisted dietary assessment methods in estimating energy and nutrient intake during controlled meals across breakfast, lunch, and dinner.
- 152 participants completed a 24-hour dietary recall after consuming meals with weights recorded, comparing results from different assessment tools, including ASA24 and Intake24.
- Findings showed that Intake24, ASA24, and mFR-TA produced more accurate energy estimates than IA-24HR, which had a significant margin of error, indicating variability in the reliability of these assessment methods.
Social health and subsequent cognitive functioning in people aged 50 years and older: examining the mediating roles of depressive symptoms and inflammatory biomarkers in two European longitudinal studies.
Lancet Healthy Longev
May 2024
MRC Unit for Lifelong Health and Ageing at UCL, Faculty of Population Health Sciences, University College London, London, UK.
Background: Social health markers, including marital status, contact frequency, network size, and social support, have been shown to be associated with cognition. However, the mechanisms underlying these associations remain poorly understood. We investigated whether depressive symptoms and inflammation mediated associations between social health and subsequent cognition.
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