Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Non-steroidal anti-inflammatory drugs and gastroprotection with proton pump inhibitors: a focus on ketoprofen/omeprazole.
Clin Drug Investig
April 2012
Clinical Orthopaedics-Department of Molecular Pathology and Innovative Therapies, Polytechnic University of Marche, Ancona, Italy.
Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed agents for rheumatic disorders such as osteoarthritis (OA), rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Despite the known association between NSAID use and gastropathy, however, only around one-third of patients at risk of NSAID-induced gastrointestinal toxicity receive adequate gastroprotection, and as many as 44% of these patients are non-adherent. We review the co-prescription of proton pump inhibitors (PPIs) for the prevention of NSAID-induced gastropathy, with a particular focus on the first fixed-dose NSAID/PPI formulation: ketoprofen/omeprazole modified-release capsules.
View Article and Find Full Text PDFAnalgesics and NSAIDs in the treatment of the acute migraine attack.
Cephalalgia
October 1995
Neurological Practice, Munich, Germany.
In the treatment of migraine attacks, an antiemetic in combination with an analgesic or ergot alkaloid is widely recommended. Medication should be introduced as early as possible, but only when there is no doubt that the headache is due to migraine. The antiemetic provides relief from the nausea and vomiting and also enhances the resorption of analgesics or ergot preparations.
View Article and Find Full Text PDFA comparison of severe gastric damage as a result of pirprofen and naproxen treatment in rheumatoid arthritis: a controlled endoscopic study.
J Intern Med
August 1994
Gastrointestinal Unit, L. Sacco Hospital, Milan, Italy.
Objective: The aim of this controlled endoscopic study was to compare the therapeutic efficacy and the gastric tolerance of two nonsteroidal anti-inflammatory drugs, pirprofen versus naproxen.
Design: A randomized endoscopic double-blind double-dummy study.
Setting: The gastrointestinal unit of a teaching hospital.
Remission of severe rheumatoid arthritis following liver transplantation.
Br J Rheumatol
September 1993
I. Department of Medicine, Johannes Gutenberg University, Germany.
We present the case of a 32-year-old male who suffered from severe RA from the age of 21 years. After 9 years of active disease and poor response to therapy the patient developed severe hepatitis induced by the NSAID pirprofen. He went into fulminant hepatic failure necessitating emergency liver transplantation.
View Article and Find Full Text PDFInfluence of the route of administration on the pharmacokinetics of pirprofen enantiomers in the rat.
Chirality
September 1993
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
The pharmacokinetics of the enantiomers of the non-steroidal anti-inflammatory drug pirprofen were studied in male Sprague-Dawley rats after oral and intravenous (iv) doses of the racemate. No significant differences were detected between the enantiomers after oral or iv dosing in t1/2, Vd, or sigma Xu. However, the R:S area under the plasma concentration (AUC) ratio after oral doses (0.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!