Genetic Suppression Meets Structure Prediction: Probing a Spore Germination Receptor Complex.

J Bacteriol

Department of Biological Sciences, Virginia Techgrid.438526.e, Blacksburg, Virginia, USA.

Published: February 2022

Despite the thousands of spore germinant receptor operons identified in genomes of bacilli and clostridia, understanding how the three essential receptor components act as a signal transduction machine in germination remains limited. The paper by Amon et al. in this issue uses the classical genetic approach of suppression to define a region of likely interaction between the GerAA and GerAB proteins: it provides a first glimpse into potential events within the receptor complex (J. D. Amon, L. Artzi, and D. Z. Rudner, J Bacteriol 204:e00470-21, 2022, https://doi.org/10.1128/JB.00470-21).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8846488PMC
http://dx.doi.org/10.1128/JB.00579-21DOI Listing

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