For several years CERN has been offering a centralised service for Elasticsearch, a popular distributed system for search and analytics of user provided data. The service offered by CERN IT is better described as a service of services, delivering centrally managed and maintained Elasticsearch instances to CERN users who have a justified need for it. This dynamic infrastructure currently consists of about 30 distinct and independent Elasticsearch installations, in the following referred to as Elasticsearch clusters, some of which are shared between different user communities. The service is used by several hundred users mainly for logs and service analytics. Due to its size and complexity, the installation produces a huge amount of internal monitoring data which can be difficult to process in real time with limited available person power. Early on, an idea was therefore born to process this data automatically, aiming to extract anomalies and possible issues building up in real time, allowing the experts to address them before they start to cause an issue for the users of the service. Both deep learning and traditional methods have been applied to analyse the data in order to achieve this goal. This resulted in the current deployment of an anomaly detection system based on a one layer multi dimensional LSTM neural network, coupled with applying a simple moving average to the data to validate the results. This paper will describe which methods were investigated and give an overview of the current system, including data retrieval, data pre-processing and analysis. In addition, reports on experiences gained when applying the system to actual data will be provided. Finally, weaknesses of the current system will be briefly discussed, and ideas for future system improvements will be sketched out.
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http://dx.doi.org/10.3389/fdata.2021.718879 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy in Hradec Králové, Charles University, Hradec Králové, Czech Republic.
Familial hypercholesterolemia (FH) is a relatively rare genetic disease associated with high serum cholesterol levels but also with abnormalities in blood coagulation. Novel pharmacotherapeutic approaches in FH including proprotein convertase subtilisin/kexin type 9 antibodies (PCSK9Ab) are very efficient in decreasing cholesterol levels but their impact on coagulation in FH is not yet established. Therefore, we hypothesized that these novel antidyslipidemic drugs can positively impact blood coagulation due to their more potent effect on cholesterol.
View Article and Find Full Text PDFJ Feline Med Surg
January 2025
Department of Clinical Science, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Objectives: Cardiovascular complications are well known in humans with autosomal dominant polycystic kidney disease (PKD), but limited data exist for cats. This study aimed to assess echocardiographic changes, cardiac troponin I (cTnI) levels and systolic blood pressure (SBP) in Persian cats with PKD to detect early cardiac abnormalities.
Methods: In total, 52 Persian and mixed-Persian cats were enrolled, with 26 cats in the control group and 26 diagnosed with PKD via ultrasound due to the unavailability of genetic testing.
Background: UFMylation is an understudied ubiquitin-like post-translational modification (PTM). Like ubiquitin, UFM1 is conjugated to substrates via a catalytic cascade involving a UFM1-specific E1 (UBA5), E2 (UFC1), and an E3 ligase complex (UFL1, DDRGK1 and CDK5RAP3). UFMylation is reversible, and this is mediated by UFSP2.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Carnegie Mellon University, Pittsburgh, PA, USA.
Background: The failure of amyloid plaque-reducing drugs to reverse cognitive decline in Alzheimer's disease (AD) has suggested that treatments might be more effective in early or prodromal stages of the disease. However, the progression of synaptic and circuit changes associated with Aβ overexpression, particularly at very early ages, have not been well-characterized. Indeed, evidence from both human and animal studies indicates that brain structure and function might be altered months to years before plaques can be detected.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Frontotemporal Disorders Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Background: Posterior Cortical Atrophy (PCA) is a syndrome characterized by a progressive decline in higher-order visuospatial processing, leading to symptoms such as space perception deficit, simultanagnosia, and object perception impairment. While PCA is primarily known for its impact on visuospatial abilities, recent studies have documented language abnormalities in PCA patients. This study aims to delineate the nature and origin of language impairments in PCA, hypothesizing that language deficits reflect the visuospatial processing impairments of the disease.
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