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Tacrolimus and diabetic rodent models.
Pharmacol Rep
January 2025
Department of Pharmacy, The First People's Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.
Tacrolimus (TAC) is an immunosuppressant widely utilized in organ transplantation. One of its primary adverse effects is glucose metabolism disorder, which significantly increases the risk of diabetes. Investigating the molecular mechanisms underlying TAC-induced diabetes is essential for developing effective prevention and treatment strategies for these adverse effects.
View Article and Find Full Text PDFInflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011-2018.
Front Nutr
January 2025
Department of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, China.
Background: Muscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic inflammation.
Methods: The analysis included 7,440 participants from the NHANES 2011-2018.
Combined effects of natural products and exercise on apoptosis pathways in obesity-related skeletal muscle dysfunction.
Apoptosis
January 2025
School of Basic Medicine, Guizhou University of Traditional Chinese Medicine, Guiyang, 550025, Guizhou, China.
Obesity and related metabolic disorders are closely linked to increased apoptosis in skeletal muscle, leading to muscle degeneration, insulin resistance, and the progression of diseases such as type 2 diabetes and sarcopenia. This review explores the combined effects of natural products, including resveratrol, curcumin, and quercetin, and physical exercise on modulating apoptosis pathways in skeletal muscle. Both natural products and regular physical activity independently reduce oxidative stress and improve mitochondrial function, thereby regulating the balance between pro-apoptotic and anti-apoptotic signals.
View Article and Find Full Text PDFExposure to Crime at Food Stores: Implications for Nutrition and Health among Black Americans.
J Community Health
January 2025
Department of Geography and Geographic Information Science, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Crime is a public health issue that disproportionately affects racially-marginalized populations. Studies have reported that food stores (e.g.
View Article and Find Full Text PDFAssociations between external eating cues, diet history and weight history in French subjects with obesity.
Appetite
January 2025
University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, Lille, France. Electronic address:
Obesity remains a serious public health concern. Historically, restrictive diets were the first line of treatment for obesity and are still frequently followed by subjects with obesity. However, some studies showed that dieting may contribute to long-term weight gain.
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