Association Analysis of , and Polymorphisms in Chinese Patients With Parkinson's Disease and Multiple System Atrophy.

The association between inflammation and neurodegeneration has long been observed in parkinson's disease (PD) and multiple system atrophy (MSA). Previous genome-wide association studies (GWAS) and meta-analyses have identified several risk loci in inflammation-associated genes associated with PD. To investigate whether polymorphisms in some inflammation-associated genes could modulate the risk of developing PD and MSA in a Southwest Chinese population. A total of 2,706 Chinese subjects comprising 1340 PD, 483 MSA and 883 healthy controls were recruited in the study. Three polymorphisms (rs2074404 GG/GT/TT, rs17425622 CC/CT/TT, rs34043159 CC/CT/TT) in genes linked to inflammation in all the subjects were genotyped by using the Sequenom iPLEX Assay. The allele G of rs2074404 can increase risk on PD (OR: 1.048, 95% CI: 1.182-1.333, = 0.006), exclusively in the LOPD subgroup (OR: 1.166, 95% CI:1.025-1.327, = 0.019), but not in EOPD or MSA. And the recessive model analysis also demonstrated an increased PD risk in GG genotype of this locus (OR = 1.331, = 0.007). However, no significant differences were observed in the genotype distributions and alleles of rs17425622 and rs34043159 between the PD patients and controls, between the MSA patients and controls, or between subgroups of PD or MSA and controls. Our results suggested the allele G of rs2074404 have an adverse effect on PD and particularly, on the LOPD subgroup among a Chinese population.