AI Article Synopsis
- Anti-M antibodies typically don't react at body temperature (37 °C), but rare cases can cause serious transfusion reactions or fetal hemolytic disease.
- A recent case highlights an acute hemolytic reaction due to an anti-M alloantibody reacting at normal temperatures in a critically ill patient.
- Effective identification and management of this type of hemolysis led to rapid improvement in the patient's condition, emphasizing the need to accurately differentiate it from other similar conditions for appropriate treatment.
Article Abstract
Introduction: Anti-M antibodies are usually inactive at physiologic temperatures (37 °C). Rarely, these antibodies have been reported to react at physiologic temperatures, resulting in clinically significant hemolytic transfusion reactions or hemolytic disease of the fetus and newborn.
Patient And Methods: We describe a case of an acute hemolytic transfusion reaction due to an anti-M alloantibody reacting at physiologic temperatures in a critically ill patient.
Results: Proper identification and management of anti-M antibody-mediated acute hemolysis rapidly improved and stabilized her hemoglobin.
Conclusion: Differentiation between anti-M antibody-mediated acute hemolysis and its differential diagnoses is of critical importance to guide therapeutic decisions in these rare clinical scenarios.
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Source |
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| http://dx.doi.org/10.1016/j.transci.2021.103284 | DOI Listing |
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