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Clinical predictors of 3-month isoniazid rifapentine (3HP)-related adverse drug reactions (ADR) during tuberculosis preventive therapy (PAnDoRA-3HP study): an observational study protocol.
BMJ Open
December 2024
Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Central, Uganda.
Introduction: Tuberculosis (TB) is the leading infectious cause of death globally. Despite WHO recommendations for TB preventive therapy (TPT), challenges persist, including incompletion of treatment and adverse drug reactions (ADRs). There is limited data on the 3-month isoniazid and rifapentine (3HP) pharmacokinetics, pharmacogenomics and their relation with ADRs.
View Article and Find Full Text PDFNew endocrine method of oral male contraception.
Contraception
December 2024
R&D Department, Pandora Endocrine Innovation, Bergen, Netherlands. Electronic address:
Essential for hormonal male contraception (HMC) is the inhibition of follicle-stimulating hormone (FSH), the hormone responsible for spermatogenesis. No drugs exist that can selectively suppress FSH without also inhibiting luteinizing hormone (LH), the hormone responsible for the biosynthesis of testosterone (T) and estradiol (E2) in men. The consequences are a loss of T and E2, with the accompanying symptoms and signs of T deficiency and E2 deficiency, respectively.
View Article and Find Full Text PDFBackground: As set out in Sustainable Development Goal 3.3, the target date for ending the HIV epidemic as a public health threat is 2030. Therefore, there is a crucial need to evaluate current epidemiological trends and monitor global progress towards HIV incidence and mortality reduction goals.
View Article and Find Full Text PDFArticle Synopsis
- Antimicrobial resistance (AMR) is a significant global health issue in the 21st century, affecting the burden of disease and mortality linked to bacterial infections across various regions.
- A comprehensive study was conducted to assess the impact of AMR from 1990 to 2021, analyzing data from 204 countries on deaths and disability-adjusted life years (DALYs) related to 22 pathogens and 84 pathogen-drug combinations.
- The researchers employed statistical modeling and extensive datasets to estimate AMR's burden, even in areas lacking direct data, considering multiple factors such as sepsis-related deaths and antibiotic resistance rates.
A dataset of hidden small non-coding RNA in the testis of heat-stressed models revealed by Pandora-seq.
Sci Data
July 2024
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, 611130, China.
Infertility, a worldwide reproductive health concern, impacts approximately one in five couples. Male infertility, stemming from spermatogenic dysfunction and reduced sperm quality, stands as a primary factor contributing to infertility. Given the global decrease in male fertility linked to environmental factors like the greenhouse effect, it is crucial to develop a comprehensive understanding of how increased temperatures impact both the quantity and quality of sperm.
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