AI Article Synopsis
- - The study explores drug repurposing for COVID-19 by analyzing how drugs can target essential host factors involved in SARS-CoV-2 infection.
- - Researchers created detailed protein-protein interaction networks to identify effective drug targets and combinations, and they validated their findings with clinical and bioinformatics data.
- - The methods used not only provide insights into COVID-19 treatment possibilities but also have broader applications for developing therapies for other diseases.
Article Abstract
To better understand the potential of drug repurposing in COVID-19, we analyzed control strategies over essential host factors for SARS-CoV-2 infection. We constructed comprehensive directed protein-protein interaction (PPI) networks integrating the top-ranked host factors, the drug target proteins and directed PPI data. We analyzed the networks to identify drug targets and combinations thereof that offer efficient control over the host factors. We validated our findings against clinical studies data and bioinformatics studies. Our method offers a new insight into the molecular details of the disease and into potentially new therapy targets for it. Our approach for drug repurposing is significant beyond COVID-19 and may be applied also to other diseases.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8690228 | PMC |
| http://dx.doi.org/10.1093/bib/bbab490 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!