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Research on bacteria isolated from ocular infections, their antibiotic susceptibility patterns and impact on selection of appropriate therapy.
New Microbiol
July 2024
Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic.
Bacterial ocular infections represent a common public health problem affecting people of all age groups. These infections can lead to damage of ocular structures or even a loss of vision. The spectrum of isolated bacteria and their susceptibilities to antibiotics, however, shows geographical variabilities, which can affect the success of most empirically-administered antimicrobial therapies.
View Article and Find Full Text PDFMolecular characterization of macrolide resistance in Haemophilus influenzae and Haemophilus parainfluenzae strains (2018-21).
J Antimicrob Chemother
September 2024
Microbiology Department, Hospital Universitari Bellvitge, IDIBELL-UB, Feixa Llarga s/n, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Objectives: This study aimed to explore the prevalence of macrolide resistance and the underlying resistance mechanisms in Haemophilus influenzae (n = 2556) and Haemophilus parainfluenzae (n = 510) collected between 2018 and 2021 from Bellvitge University Hospital, Spain.
Methods: Antimicrobial susceptibility was tested by microdilution. Whole-genome sequencing was performed using Illumina MiSeq and Oxford Nanopore technologies, and sequences were examined for macrolide resistance determinants and mobile genetic structures.
Antimicrobial Susceptibility of Bacterial Pathogens from Patients with Ocular Surface Infections in Germany, 2020-2021: A Comparison with the Data from Three Previous National Studies.
Antibiotics (Basel)
May 2024
Antiinfectives Intelligence GmbH, c/o Rechtsrheinisches Technologie- und Gründerzentrum, Gottfried-Hagen-Straße 60-62, 51105 Cologne, Germany.
Bacteria are a major cause of superficial eye infections, especially in children. The present study aimed to (i) determine the antimicrobial susceptibility patterns of ocular bacterial pathogens recovered in 20 laboratories during the period 2020-2021 and (ii) compare these results to those from three studies of the same design conducted in 2004, 2009, and 2015 in Germany. Cut-off values defined by EUCAST were used as breakpoints.
View Article and Find Full Text PDFMembranome-based identification of amino acid substitution in Haemophilus influenzae multidrug efflux pump HmrM for reduced chloramphenicol susceptibility.
Arch Microbiol
June 2024
Department of Laboratory Medicine, E-DA Hospital, Kaohsiung, Taiwan.
Article Synopsis
- The study investigates chloramphenicol susceptibility in Haemophilus influenzae, focusing on the role of chloramphenicol acetyltransferases (CATs) and membrane proteins.
- Six H. influenzae isolates were resistant to chloramphenicol and had type A-2 CATs, with one isolate showing unique membrane gene variations that impacted its resistance.
- Analyses revealed specific genetic variations in membrane proteins related to both enhanced and reduced susceptibility to chloramphenicol, providing insights into how these proteins can affect antibiotic resistance in CAT-negative isolates.
Characterizing in Southern Vietnam between 2012 and 2021: A predominance of the chloramphenicol-resistant ST-1576 lineage.
IJID Reg
March 2024
Department for Disease Control and Prevention, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
Objectives: Our goal was to describe Invasive Meningococcal Disease (IMD) in Southern Vietnam over the last 10 years. We characterized 109 strains in Southern Vietnam isolated between 1980s to 2021, that were collected from IMD (n = 44), sexually transmitted infections (n = 2), and healthy carriage (n = 63).
Methods: IMD were confirmed by bacterial culture and/or real-time polymerase chain reaction at the national reference laboratory in Pasteur Institute of Ho Chi Minh City (PIHCM).
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