AI Article Synopsis
- Photodynamic Therapy (PDT) is a cancer treatment that uses reactive oxygen species to kill cancer cells, focusing on gliosarcoma in this study.
- The researchers used protoporphyrin IX as a photosensitizer, along with a precursor called aminolevulinic acid (ALA), to determine the most effective treatment parameters.
- Results showed that the success of PDT was influenced by ALA concentration and required a 4-hour incubation before treatment, leading to cell death primarily through necrosis 18 hours afterward.
Article Abstract
Photodynamic Therapy (PDT) is an oncologic treatment, producing reactive oxygen species (ROS) to induce the death of cancer cells. This study aimed to evaluate the action of PDT on gliosarcoma cells, using protoporphyrin IX as PS by incubation with the precursor aminolevulinic acid (ALA). An LED device was used with a light dose of 10 J/cm². The success of the therapy proved to be dependent on the concentration of ALA, and an incubation time of 4 h required for an effective response. Cell death was prevalent due to necrosis when assessed 18 h post-PDT. ALA proved to be an option to PDT in cells of the 9 L/lacZ, with the protocol tested.
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| http://dx.doi.org/10.1016/j.pdpdt.2021.102669 | DOI Listing |
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