Living donor liver transplantation (LDLT) remains underutilized in the United States. Barriers to LDLT and acceptance of nondirected living liver donation (ND-LLD) and liver paired exchange (LPE) are unclear. The medical and surgical directors of 99 unique transplantation programs (56 LDLT programs and 43 non-LDLT programs) were surveyed to gain insight into perceptions and practices of LDLT and types of donors utilized. The response rate was 84%. Most LDLT programs (65%) reported performing ND-LLD, though opinions regarding allocation and the need for additional evaluation of these donors were mixed. Only a minority of LDLT programs reported performing LPE (12%), but most programs (78%) would be open to cross-institutional LPE barring logistical barriers. There were significant differences between LDLT and non-LDLT programs with regard to perceived barriers to LDLT, with LDLT programs reporting mainly donor and recipient factors and non-LDLT programs reporting institutional factors (P < 0.001). Understanding perceptions and practices of LDLT, ND-LLD, and LPE is important to aid in the growth of LDLT.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9018478 | PMC |
| http://dx.doi.org/10.1002/lt.26384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Early outcomes of robotic vs open living donor right hepatectomy in a US Center.
Surg Endosc
January 2025
Division of Transplant Surgery, Department of Surgery, Hume- Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, VA, USA.
Background: Robotic living donor hepatectomy offers potential advantages but has been limited to high-volume centers, primarily in Asia and the Middle East. We report our experience establishing a robotic living donor right hepatectomy program in a U.S.
View Article and Find Full Text PDFThe role of living donor liver transplantation in colorectal cancer liver metastases.
Curr Opin Organ Transplant
February 2025
Division of General Surgery, Department of Surgery, University of Toronto.
Purpose Of Review: Despite technical and therapeutic advances, only 20-40% of patients with colorectal liver metastases (CRLM) have resectable disease. Historically, the remaining patients with unresectable, liver-only CRLM would receive palliative chemotherapy, with a median survival of 8 months.
Recent Findings: Liver transplantation has emerged as a viable option for selected patients with CRLM.
The Pre-/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT.
Curr Issues Mol Biol
November 2024
Liver Transplantation Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan.
This study aimed to investigate the relationship between the IL-28B SNP rs8099917 genotype, miRNA-122 expression, and the immune mechanism of ACR after LT using anti-HCV antibody calibration. A total of 45 patients with HCV received LT. IL-28B SNP rs8099917 genotyping was used to divide patients into TT and GT groups.
View Article and Find Full Text PDFMultiple Swaps Tested: Rehearsal for Triple and Five Liver Paired Exchanges.
Transplant Proc
November 2024
Liver Transplantation Institute, Inonu University, Malatya, Turkey.
Despite several advances in living donor liver transplant (LDLT), many potential living liver donors cannot donate their organs to their relatives because of blood group incompatibility and unsuitable anatomy. Liver paired exchange (LPE) can be used to overcome incompatibilities between living donor-recipient pairs. In this study, we report the early and late results of three and five LDLTs performed simultaneously to initiate the more complex LPE program.
View Article and Find Full Text PDFExploring Anesthesiology Management of Living Donor Liver Transplantation: Survey From the Society for the Advancement of Transplant Anesthesia and the Korean Society for Transplantation Anesthesiologists.
Clin Transplant
October 2024
Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- The study compares anesthetic management practices between living donor liver transplantation (LDLT) in South Korea and the United States, revealing significant differences despite high response rates from anesthesiology directors in both countries.
- Key disparities include rates of early extubation post-surgery, involvement in donor selection meetings, application of enhanced recovery protocols, and use of cell savers for donors, highlighting varying approaches to patient care.
- Overall, the findings emphasize the need for further investigation into how these differences may affect patient outcomes in LDLT procedures across these two nations.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!