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A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern. | LitMetric

AI Article Synopsis

  • New SARS-CoV-2 variants, especially the Beta variant from South Africa, are making it harder to fight COVID-19 by resisting antibody neutralization.
  • Vaccines based on the original virus sequence remain effective but show reduced efficacy against these new variants.
  • Research on mice, rabbits, and non-human primates indicates that a third dose of the Wuhan-based Spike vaccine significantly boosts neutralizing antibodies, restoring protection levels against variants like Beta to those observed with the original strain after two doses.

Article Abstract

The emergence of SARS-CoV-2 variants that are more resistant to antibody-mediated neutralization pose a new hurdle in combating the COVID-19 pandemic. Although vaccines based on the original Wuhan sequence have been shown to be effective at preventing COVID-19, their efficacy is likely to be decreased against more neutralization-resistant variants-of-concern (VOC), in particular, the Beta variant originating in South Africa. We assessed, in mice, rabbits, and non-human primates, whether a third vaccination with experimental Wuhan-based Spike vaccines could alleviate this problem. Our data show that a third immunization improves neutralizing antibody titers against the variants-of-concern, Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1), and Delta (B.1.617.2). After three vaccinations, the level of neutralization against Beta was similar to the level of neutralization against the original strain after two vaccinations, suggesting that simply providing a third immunization could nullify the reduced activity of current vaccines against VOC.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8642392PMC
http://dx.doi.org/10.1038/s41541-021-00411-7DOI Listing

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