For causal knowledge to be worth learning, it must remain valid when that knowledge is applied. Because unknown background causes are potentially present, and may vary across the learning and application contexts, extricating the strength of a candidate cause requires an assumption regarding the decomposition of the observed outcome into the unobservable influences from the candidate and from background causes. Acquiring stable, useable causal knowledge is challenging when the search space of candidate causes is large, such that the reasoner's current set of candidates may fail to include a cause that generalizes well to an application context. We have hypothesized that an indispensable navigation device that shapes our causal representations toward useable knowledge involves the concept of causal invariance - the sameness of how a cause operates to produce an effect across contexts. Here, we tested our causal invariance hypothesis by making use of the distinct mathematical functions expressing causal invariance for two outcome-variable types: continuous and binary. Our hypothesis predicts that, given identical prior domain knowledge, intuitive causal judgments should vary in accord with the causal-invariance function for a reasoner's perceived outcome-variable type. The judgments are made as if the reasoner aspires to formulate causally invariant knowledge. Our experiments involved two cue-competition paradigms: blocking and overexpectation. Results show that adult humans tacitly use the appropriate causal-invariance functions for decomposition. Our analysis offers an explanation for the apparent elusiveness of the blocking effect and the adaptiveness of intuitive causal inference to the representation-dependent reality in the mind.
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http://dx.doi.org/10.1016/j.cogpsych.2021.101432 | DOI Listing |
Biomolecules
January 2025
Department of Immunology, School of Medicine, Semnan University of Medical Sciences, Semnan 35147-99442, Iran.
Traditionally, research on the adaptive immune system has focused on protein antigens, but emerging evidence has underscored the essential role of lipid antigens in immune modulation. Lipid antigens are presented by CD1 molecules and activate invariant natural killer T (iNKT) cells and group 1 CD1-restricted T cells, whereby they impact immune responses to pathogens and tumors. Recent advances in mass spectrometry, imaging techniques, and lipidomics have revolutionized the identification and characterization of lipid antigens and enhanced our understanding of their structural diversity and functional significance.
View Article and Find Full Text PDFArch Virol
January 2025
Facultad de Estudios Superiores Cuautitlán, Departamento de Ciencias Biológicas, Universidad Nacional Autónoma de México (UNAM), Carretera Cuautitlán-Teoloyucan Km 2.5, Cuautitlán Izcalli, 54714, Estado de México, México.
Porcine parvovirus 5 (PPV5) is an unclassified member of the family Parvoviridae with no reported pathogenicity, although it is associated with multisystemic, reproductive, and respiratory diseases. Its open reading frame 1 (ORF1) encodes non-structural protein 1 (NS1), which is predicted to have helicase activity that is essential for viral replication. This protein contains a C-motif with an invariant asparagine residue that forms the core of the enzyme's active site, in conjunction with the Walker A and B motifs.
View Article and Find Full Text PDFEpidemiology
January 2025
Center for Communicable Disease Dynamics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
During the coronavirus disease (COVID-19) pandemic, researchers attempted to estimate the number of averted and avertible outcomes due to vaccination campaigns to quantify public health impact. However, the estimands used in these analyses have not been previously formalized. It is also unclear how these analyses relate to the broader framework of direct, indirect, total, and overall causal effects under interference.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Cellular and Structural Physiology Laboratory, Advanced Research Initiative, Institute of Integrated Research, Institute of Science Tokyo, Bunkyo-ku, Tokyo 113-8510, Japan.
Pathogen mutations present an inevitable and challenging problem for therapeutics and the development of mutation-tolerant anti-infective drugs to strengthen global health and combat evolving pathogens is urgently needed. While spike proteins on viral surfaces are attractive targets for preventing viral entry, they mutate frequently, making it difficult to develop effective therapeutics. Here, we used a structure-guided strategy to engineer an inhibitor peptide against the SARS-CoV-2 spike, called CeSPIACE, with mutation-tolerant and potent binding ability against all variants to enhance affinity for the invariant architecture of the receptor-binding domain (RBD).
View Article and Find Full Text PDFEntropy (Basel)
January 2025
Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing 100190, China.
Multimedia recommendation systems aim to accurately predict user preferences from multimodal data. However, existing methods may learn a recommendation model from spurious features, i.e.
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