Organogenesis is orchestrated by the interaction of different embryonic tissues. Recent reports in Cell Stem Cell (Silva et al., 2021; Rossi et al., 2021) and Nature Biotechnology (Drakhlis et al., 2021) recapitulate the co-development of embryonic mesoderm and endoderm in PSCs to promote formation of complex heart and gut organoids.
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http://dx.doi.org/10.1016/j.stem.2021.09.003 | DOI Listing |
Soft Matter
September 2021
Institut Charles Sadron, CNRS - UPR 22, Université de Strasbourg, 23 rue du Loess, BP 84047, 67034 Strasbourg Cedex 2, France.
Equilibrium and dynamical properties of a two-dimensional polydisperse colloidal model system are characterized by means of molecular dynamics (MD) and Monte Carlo (MC) simulations. We employed several methods to prepare quasi-equilibrated systems: in particular, by slow cooling and tempering with MD (method SC-MD), and by tempering with MC dynamics involving swaps of particle diameters (methods Sw-MD, Sw-MC). It is revealed that the Sw-methods are much more efficient for equilibration below the glass transition temperature T leading to denser and more rigid systems which show much slower self-diffusion and shear-stress relaxation than their counterparts prepared with the SC-MD method.
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