Follow your heart and trust your gut: Co-development of heart and gut tissue in organoids.

Cell Stem Cell

Center for Stem Cell and Organoid Medicine (CuSTOM), Perinatal Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA. Electronic address:

Published: December 2021

Organogenesis is orchestrated by the interaction of different embryonic tissues. Recent reports in Cell Stem Cell (Silva et al., 2021; Rossi et al., 2021) and Nature Biotechnology (Drakhlis et al., 2021) recapitulate the co-development of embryonic mesoderm and endoderm in PSCs to promote formation of complex heart and gut organoids.

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http://dx.doi.org/10.1016/j.stem.2021.09.003DOI Listing

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