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Perioperative outcomes in an age-adapted analysis of the German StuDoQ|Pancreas registry for PDAC.
BMC Surg
January 2025
Department of General, Visceral and Transplantation Surgery, LMU University Hospital Munich, LMU Munich, Munich, Germany.
Background: Pancreatic ductal adenocarcinoma (PDAC) typically occurs in an older patient population. Yet, early-onset pancreatic cancer (EOPC) has one of the fastest growing incidence rates. This study investigated the influence of age and tumor location on postoperative morbidity and mortality in a large, real-world dataset.
View Article and Find Full Text PDFAspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus.
Gut
January 2025
Department of Medicine, School of Clinical Medicine, The University of Hong Kong, Hong Kong, Hong Kong
Background: Patients with type 2 diabetes mellitus (T2DM) have higher pancreatic cancer (PC) risk. While aspirin has chemopreventive effects on digestive cancers, its effect on PC among patients with T2DM is unclear.
Methods: This retrospective cohort study identified newly diagnosed adult patients with T2DM in Hong Kong between 2001 and 2015 from a territory-wide healthcare registry.
The Effects of Perioperative Corticosteroids on Postoperative Complications After Pancreatoduodenectomy: A Debated Topic of Systematic Review and Meta-analysis.
Ann Surg Oncol
January 2025
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Article Synopsis
- The study examines the effects of intraoperative corticosteroids on postoperative complications in patients undergoing pancreatoduodenectomy (PD), finding no significant improvement in major complications or specific issues like pancreatic fistulas or infections.
- A meta-analysis of 5 studies involving 1,449 patients revealed no difference in outcomes between those who received corticosteroids and those who did not across various complications measured.
- The conclusion suggests that corticosteroids do not provide a protective advantage in this surgical context, emphasizing the need for further clinical trials to gather more robust evidence.
Association of mental health assessment with postoperative outcomes following major surgery in older individuals.
Surgery
December 2024
Department of Surgery, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, OH. Electronic address:
Introduction: Individuals with mental illness are at risk for poor surgical outcomes. Notably, the impact of preoperative assessment and optimization for high-risk surgical procedures remains a relatively understudied and evolving field. We sought to investigate the association between mental health assessment and postoperative outcomes.
View Article and Find Full Text PDFImpact of Metastatic Pattern on Survival Following Pancreatectomy for Cancer.
J Surg Oncol
December 2024
The Hiram C. Polk, Jr., MD Department of Surgery, Division of Surgical Oncology, University of Louisville School of Medicine, Louisville, Kentucky, USA.
Background And Methods: The incidence of pancreatic cancer is increasing, and up to 55% of patients present with metastatic disease at the time of diagnosis. Many patients also develop metastatic disease following surgical resection. The impact of metastatic patterns on outcomes has not been described.
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