Iatrogenic Metastasis of Soft-tissue Sarcoma at the Donor Flap Site: Case Report and Proposed Surgical Oncologic Techniques.

J Am Acad Orthop Surg Glob Res Rev

From the Division of Orthopaedic Oncology (Dr. LiBrizzi, Dr. Rao, Dr. Levin, and Dr. Morris), Department of Orthopaedic Surgery, Department of Plastic and Reconstructive Surgery (Dr. Tuffaha), and the Department of Pathology (Dr. Gross), The Johns Hopkins University School of Medicine, Baltimore MD.

Published: December 2021

AI Article Synopsis

  • * Six years later, she experienced a recurrence of cancer at the site where the tissue was harvested, linked to the surgical process.
  • * The article emphasizes methods and surgical guidelines to minimize the risk of cancer spread caused by surgical techniques, urging better awareness and practices among surgical teams.

Article Abstract

An 81-year-old woman with multiply recurrent undifferentiated pleomorphic sarcoma of the foot underwent wide excision and reconstruction with an anterolateral thigh free flap. Six years postoperatively, she developed biopsy-proven recurrence within the harvest site. No other sites of disease were detected on staging workup. The flap site recurrence was attributed to iatrogenic implantation at the time of harvesting. Iatrogenic metastases are thought to be caused by tumor implantation, which may be attributable to cross-contamination from instrumentation and surgical techniques. In the present article, we highlight preventive techniques and oncologic surgical principles intended to reduce the likelihood of iatrogenic metastasis. Increased awareness by all members of the surgical team may prevent this unfortunate complication.

Download full-text PDF

Source
http://dx.doi.org/10.5435/JAAOSGlobal-D-21-00208DOI Listing

Publication Analysis

Top Keywords

iatrogenic metastasis
8
flap site
8
iatrogenic
4
metastasis soft-tissue
4
soft-tissue sarcoma
4
sarcoma donor
4
donor flap
4
site case
4
case report
4
report proposed
4

Similar Publications

Background: Retinoblastoma (Rb) is the most common intraocular malignancy of childhood. The prognosis in Rb directly relates to the spread of disease beyond the eye, particularly to the central nervous system. Therefore, until the recent past, surgically entering an eye with active or recently active Rb was absolutely contraindicated in most centres around the world due to the risk of iatrogenic extraocular spread.

View Article and Find Full Text PDF

A critical analysis of design, binding pattern and SAR of benzo-fused heteronuclear compounds as VEGFR-2 inhibitors.

Bioorg Med Chem

December 2024

Drug Design and Synthesis Lab, Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala, India.

Vascular endothelial growth factors (VEGFs) are a class of homodimeric ligands that bind to their receptors (VEGFRs) to carryout physiological and pathological angiogenesis essential for regulating homeostasis of body. Overexpression of VEGF results in metastasis of benign tumor into malignant tumor. An active role of VEGFR-2 in cancer angiogenesis makes it a major target for cancer therapy.

View Article and Find Full Text PDF

Thermal ablation is used to treat liver metastasis including those from breast cancer. The ablation is associated with pain, hemorrhage, and biliary structure damage leading to bilomas. Biloma is a collection of bile that can occur inside or outside the biliary system, which could happen as a rare complication of surgery (from procedures like abdominal surgery or diagnostic procedures), trauma, or spontaneously.

View Article and Find Full Text PDF

A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood.

View Article and Find Full Text PDF
Article Synopsis
  • Upper tract transitional cell carcinoma is difficult to diagnose due to its common occurrence and varied symptoms.
  • A case involved a 48-year-old man with heart disease and a kidney stone, where high-grade carcinoma was found during ureteroscopy to remove the stone.
  • The unusual structure of the kidney's calyceal diverticulum may increase the risk of the cancer spreading, underscoring the need for careful surgical practices to prevent tumor cell dissemination.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!