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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome.
Cell Discov
January 2025
Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain.
A well-balanced ion channel trafficking machinery is paramount for the normal electromechanical function of the heart. Ion channel variants and many drugs can alter the cardiac action potential and lead to arrhythmias by interfering with mechanisms like ion channel synthesis, trafficking, gating, permeation, and recycling. A case in point is the Long QT syndrome (LQTS), a highly arrhythmogenic disease characterized by an abnormally prolonged QT interval on ECG produced by variants and drugs that interfere with the action potential.
View Article and Find Full Text PDFDevelopment of a framework to structure decision-making in environmental and occupational health: A systematic review and Delphi study.
Environ Int
December 2024
Cochrane Canada and McMaster GRADE Centres & Department of Health Research Methods, Evidence and Impact, McMaster University, Health Sciences Centre, Room 2C14, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada; School of Medicine, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA. Electronic address:
Background: Environmental and occupational health (EOH) assessments increasingly utilize systematic review methods and structured frameworks for evaluating evidence about the human health effects of exposures. However, there is no prevailing approach for how to integrate this evidence into decisions or recommendations. Grading of Recommendations Assessment, Development and Evaluation (GRADE) evidence-to-decision (EtD) frameworks provide a structure to support standardized and transparent consideration of relevant criteria to inform health decisions.
View Article and Find Full Text PDFComments on "Tonsillar tuberculosis mimicking tonsillar carcinoma: A case report" based on ChatGPT approach.
Int J Surg Case Rep
January 2025
Department of Internal Medicine, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran. Electronic address:
Invasive infections by group A Streptococcus infections in Brazil: a pediatric case series.
Rev Paul Pediatr
January 2025
Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Objective: Group A Streptococcus (GAS) are Gram-positive cocci that colonize the nasopharynx and/or skin and in rare cases may cause severe invasive infections. Although these infections decreased during the COVID-19 pandemic, some countries have observed an increased number of invasive GAS (iGAS) diseases in recent years. The objective of this study was to describe a series of iGAS diseases in a referral hospital for the treatment of pediatric infectious disease in Minas Gerais State, Brazil, between September 2022 and August 2023.
View Article and Find Full Text PDFComment on: "Cardiac arrest due to coronary vasospasm after sugammadex administration-a case report".
Korean J Anesthesiol
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Division of Neuroanaesthesiology, International Institute of Neurosciences, Aster Whitefield Hospital, Bengaluru, Karnataka, India.
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