Aim: To evaluate the effects of factors, which are associated with carpal tunnel syndrome (CTS) prevalence, on disease severity.
Material And Methods: This retrospective study included 206 patients who were treated surgically for either moderate or severe CTS. Patients were grouped into moderate and severe CTS then compared regarding to age, gender, BMI, and presence of occupational factors as well as systemic diseases that are associated with CTS.
Results: Patients with moderate and severe CTS did not differ in age, gender, occupational risk factors, and most of the systemic diseases, including DM, hypothyroidism, rheumatoid arthritis, cardiovascular disease, renal insufficiency, and folate deficiency. The severe CTS group had a significantly higher BMI than the moderate CTS group. Moreover, vitamin B12 deficiency was significantly more common in the severe CTS group than in the moderate CTS group.
Conclusion: Patients with severe CTS are more inclined toward surgery than those with moderate CTS. Controlling BMI and preventing vitamin B12 deficiency may help keep alleviate complaints related to CTS with less invasive treatment modalities.
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http://dx.doi.org/10.5137/1019-5149.JTN.34519-21.2 | DOI Listing |
Acad Radiol
January 2025
Department of Orthopedics and Traumatology, Samsun University Faculty of Medicine, Samsun, Turkey (A.E.O.).
Rationale And Objectives: This study aimed to evaluate the efficacy of ultrasound (US)-guided local steroid injection in carpal tunnel syndrome (CTS) using shear wave elastography (SWE).
Materials And Methods: A total of 47 wrists from 41 patients diagnosed with mild to moderate idiopathic CTS, based on clinical and electrophysiological criteria, were enrolled between June and October 2024. All participants underwent US-guided local steroid injection.
Surg Neurol Int
December 2024
Department of Surgery, Medical College, King Faisal University, Hofuf, Ahsa, Saudi Arabia.
Background: Carpal tunnel syndrome (CTS) is a common nerve entrapment condition, and there is ongoing debate regarding the superiority of traditional open versus minimally invasive carpal tunnel surgery.
Methods: This meta-analysis reviewed six studies involving 478 patients to compare recovery and functional outcomes between the traditional longitudinal technique and the minimally invasive mini-transverse technique. The primary outcomes included the functional status scale (FSS), symptoms severity scale (SSS), pain scores, time to return to work, duration of operation, and incidence of complications.
J Hand Surg Asian Pac Vol
January 2025
Department of Orthopaedic Surgery, Kochi Medical School, Kochi University, Nankoku, Japan.
Carpal tunnel syndrome (CTS) due to amyloid deposition was reported to precede fatal cardiac amyloidosis by several years. Although nerve conduction study (NCS) supports CTS diagnosis, the incidence of positive amyloid deposition in electrophysiologically proven CTS is unclear. We retrospectively analysed the demographic data including age, gender, bilateral hand involvement, amyloid deposition and NCS results, of 111 consecutive CTS patients with postoperative symptom improvement (mean 71.
View Article and Find Full Text PDFJ Hand Surg Am
January 2025
Musculoskeletal Translational Innovation Initiative, Carl J. Shapiro Department of Orthopaedic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.
Carpal tunnel syndrome (CTS) is the most common compression neuropathy. The median nerve contains sensory, motor, and sympathetic fibers. Involvement of the different fibers of the median nerve in CTS may vary; hence, one of the sensory, motor, or autonomic dysfunctions may be dominant.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Department of Biosciences, Biotechnology and Environment, University of Bari Aldo Moro, 70125 Bari, Italy.
Mutations in the SLC25A38 gene are responsible for the second most common form of congenital sideroblastic anemia (CSA), a severe condition for which no effective treatment exists. We developed and characterized a K562 erythroleukemia cell line with markedly reduced expression of the SLC25A38 protein (A38-low cells). This model successfully recapitulated the main features of CSA, including reduced heme content and mitochondrial respiration, increase in mitochondrial iron, ROS levels and sensitivity to oxidative stress.
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