AI Article Synopsis
- IgG4-related disease (IgG4-RD) is a chronic inflammatory condition that can affect different organs, but is rarely seen in the mammary glands.
- A 54-year-old woman had a mammary ultrasonography that showed an irregular tumor in her left breast, raising concerns about breast cancer.
- A biopsy confirmed the presence of mixed immune cell infiltration and an abnormal IgG4 level, leading to a diagnosis of IgG4-related mastitis (IgG4-RM) instead of cancer.
Article Abstract
Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a group of chronic relapsing inflammatory conditions. Although IgG4-RD can occur in various organs, it is rarely observed in mammary glands. Here, we report a case of IgG4-related mastitis (IgG4-RM) that needed to be differentiated from breast cancer. A 54-year-old woman was examined for a tumor in her left breast. Mammary ultrasonography revealed an irregular hypoechoic tumor measuring 45.0 × 43.0 × 32.0 mm in size. A core-needle biopsy of the left breast tissue revealed a high degree of mixed T and B lymphocytic and plasma cell infiltration, as well as interstitial fibrosis. IgG4-RD was diagnosed based on hematological examination that revealed an abnormal IgG4 value of 332 mg/dl. All the clinical diagnostic criteria for IgG4 were met, resulting in a definitive diagnosis of IgG4-RM.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8634083 | PMC |
| http://dx.doi.org/10.1093/jscr/rjaa240 | DOI Listing |
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