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Impact of single nucleotide polymorphisms (SNPs) in antioxidant-enzyme genes on the concentrations of folate, homocysteine and glutathione in plasma from healthy subjects after folic acid supplementation - a randomized controlled crossover trial.
Genes Nutr
January 2025
Department of Nutrition, University of Oslo (UiO), Oslo, Norway.
Background: One-carbon metabolism links folate and methionine metabolism and this is essential for nucleotide synthesis in the cells. Alterations in one-carbon metabolism are associated with cardiovascular disease (CVD), type 2 diabetes and cancer. Our aim was to investigate whether SNPs in antioxidant-enzyme genes impact the concentrations of folate in serum (s-folate), plasma total homocysteine (p-tHcy) and total glutathione in plasma (p-tGSH) in healthy subjects after supplementation with folic acid.
View Article and Find Full Text PDFMethionine mitigates aflatoxicosis in quail chicks by improving gut microbiota, immunity, and meat quality.
Toxicol Rep
June 2025
Department of Animal Sciences, Faculty of Agriculture, University of Zabol, Sistan 98661-5538, Iran.
This study aimed to investigate the effects of dietary methionine (Met) supplementation on performance, immunity, and meat quality in growing Japanese quail exposed to aflatoxin B (AFB)-contaminated diets. Nine experimental diets were formulated, incorporating three levels of dietary Met (5.0, 6.
View Article and Find Full Text PDFCreatine monohydrate administration delayed muscle glycolysis of antemortem-stressed broilers by enhancing muscle energy status, increasing antioxidant capacity and regulating muscle metabolite profiles.
Poult Sci
January 2025
College of Animal Science and Technology, Qingdao Agricultural University, Qingdao 266000, China; Department of Biology and Agriculture, Zunyi Normal College, Ping`an Avenue, Hong Huagang District, Zunyi 563006, China.
Preslaughter stress induced a negative energy balance of broilers, resulted in an accelerated glycolysis and finally led to an inferior meat quality. The present study aimed to investigate the effects of creatine monohydrate (CMH) supplementation on muscle energy storage, antioxidant capacity, the glycolysis of postmortem muscle and the metabolite profiles in muscle of broilers subjected to preslaughter transport. Two hundred and forty broilers were chosen and randomly allocated into three treatments (group A, group B and group C), comprising 8 replicates (10 broilers each replicate).
View Article and Find Full Text PDFActivation of the De Novo Serine Synthesis Pathway and Disruption of Insulin Signaling Induced by Supplemental SeMet in Vitro.
Biol Trace Elem Res
January 2025
Department of Nutrition and Metabolism, Chinese Center for Disease Control and Prevention, National Institute for Nutrition and Health, Beijing, 100050, China.
Selenium (Se) intake or selenoprotein overexpression can cause abnormal glucose metabolism and increase the risk of type 2 diabetes (T2D). The purpose of this study is to observe whether glycolysis bypass in the de novo serine synthesis pathway (SSP) is activated under high-Se stress in vitro. Initially, HCT-116, L02, HepG2, and differentiated C2C12 cells were exposed to five selenomethionine (SeMet) concentrations (0.
View Article and Find Full Text PDFArsenic Exposure Triggers Nonalcoholic Fatty Liver Disease through Repressing -Adenosylmethionine-Dependent Histone Methylation in Rats.
Environ Sci Technol
January 2025
Key Laboratory of Urban Environment and Health, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, China.
Arsenic (As) is a toxic metalloid widespread in the environment, and its exposure has been associated with a variety of adverse health outcomes. As exposure is demonstrated to cause nonalcoholic fatty liver disease (NAFLD), and the underlying epigenetic mechanisms remain largely unknown. This study aimed to investigate the roles of histone modifications in low-level As exposure-induced NAFLD in rats.
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