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| http://dx.doi.org/10.1186/s12913-021-07091-y | DOI Listing |
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Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Splice-switching oligonucleotides (SSOs) can restore protein functionality in pathologies and are promising tools for manipulating the RNA-splicing machinery. Delivery vectors can considerably improve SSO functionality in vivo and allow dose reduction, thereby addressing the challenges of RNA-targeted therapeutics. Here, we report a biocompatible SSO nanocarrier, based on redox-responsive disulfide cross-linked low-molecular-weight linear polyethylenimine (cLPEI), for overcoming multiple biological barriers from subcellular compartments to en-route serum stability and finally in vivo delivery challenges.
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Institute for General Microbiology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany.
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View Article and Find Full Text PDFEffect of Hubbard U-corrections on the electronic and magnetic properties of 2D materials: a high-throughput study.
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