Two new diterpenoids from the stems of as GABA receptor agonists.

J Asian Nat Prod Res

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Published: June 2022

Two new diterpenoids, dauricumins A () and B (), together with two known aromatic meroterpenoids ( and ), were isolated from the petroleum ether soluble fraction of the stems from through an HPLC-MS-SPE-NMR combination strategy. The absolute configurations of and were elucidated by ECD calculations and [Rh (OCOCF)]-induced CD spectrum analysis. In a membrane potential FLIPR assay, confluentin () showed an agonistic effect on GABA receptor (EC = 20 µM).

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http://dx.doi.org/10.1080/10286020.2021.2007089DOI Listing

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