The course of the COVID-19 pandemic is commonly evaluated using the 7-day Incidence. We propose using 1) Incidence(t+14), an index for the theoretical course of the pandemic in the absence of lockdown, as a basis for making real-time interventions. 2) The derived parameters t(t) and t(S), obtained with the SIZ algorithm and the Bateman function, for estimating of the required degree of herd immunity to stop the pandemic. The current value of t(t) for Germany is ~ 1.8 days, indicating that the percentage herd immunity required to halt the pandemic, assuming an efficacy of vaccination of 90%, is at least 87%.
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http://dx.doi.org/10.5414/CPP60001 | DOI Listing |
Int J Med Sci
January 2025
Department of Biological Sciences, College of Science, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia.
The outbreak of COVID-19 has opened up new avenues for exploring the importance of vitamin D in immunity, in addition to its role in calcium absorption. Recently, vitamin D supplementation has been found to enhance T regulatory lymphocytes, which are reduced in individuals with COVID-19. Increased risk of pneumonia and increases in inflammatory cytokines have been reported to be major threats associated with vitamin-D deficiency.
View Article and Find Full Text PDFVet Clin North Am Food Anim Pract
January 2025
Department of Veterinary and Biomedical Sciences, Animal Disease Research and Diagnostic Laboratory, South Dakota State University, Brookings, SD 57007, USA.
Respiratory disease in cattle and small ruminants is caused by various factors, including inadequate biosecurity and biocontainment. Biosecurity and biocontainment depend on good husbandry. Testing on arrival and quarantining for 42 to 56 days could improve biosecurity.
View Article and Find Full Text PDFSci Rep
January 2025
Gunma University, 1-5-1 Tenjin-Cho, Kiryu, 376-8515, Japan.
With the emergence of COVID-19 variants and new viruses, it remains uncertain when the next pandemic will occur. A lockdown is considered the last resort to halt the spread of infection; however, it causes significant economic and social damage. Therefore, exploring less harmful alternatives during such scenarios is crucial.
View Article and Find Full Text PDFVaccines (Basel)
November 2024
FSBSI 'Institute of Experimental Medicine', 197022 Saint Petersburg, Russia.
Background/objectives: Humoral immunity directed against neuraminidase (NA) of the influenza virus may soften the severity of infection caused by new antigenic variants of the influenza viruses. Evaluation of NA-inhibiting (NI) antibodies in combination with antibodies to hemagglutinin (HA) may enhance research on the antibody response to influenza vaccines.
Methods: The study examined 64 pairs of serum samples from patients vaccinated with seasonal inactivated trivalent influenza vaccines (IIVs) in 2018 according to the formula recommended by the World Health Organization (WHO) for the 2018-2019 flu season.
Int J Environ Res Public Health
November 2024
Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.
The literature associating the spread of SARS-CoV-2 with the healthcare-related, geographical, and demographic characteristics of the territory is inconclusive and contrasting. We studied these relationships during winter 2021/2022 in South Tyrol, a multicultural Italian alpine province, performing an ecological study based on the 20 districts of the area. Data about incidence, hospitalization, and death between November 2021 and February 2022 were collected and associated to territorial variables via bivariate analyses and multivariate regressions.
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