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Biomarkers.
Alzheimers Dement
December 2024
Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: Trisomy 21 in Down syndrome (DS) is associated with an earlier accumulation of beta-amyloid (Aβ) plaques and a higher rate of Alzheimer's Disease due to the triplication of the amyloid precursor protein gene. In this study we compare accumulation rates of Aβ measured with [C-11]PiB PET between large longitudinal cohorts of DS and neurotypical (NT) participants at a single site.
Methods: Participants imaged at the University of Wisconsin with ≥2 PiB scans and ≥2 years between scans were included in this study.
Background: Current tools for Alzheimer's disease screening and staging used in clinical research (e.g. ACE-3, ADAS-Cog) require substantial face-to-face time with trained professionals, and may be affected by subjectivity, "white coat syndrome" and other biases.
View Article and Find Full Text PDFDeveloping Topics.
Alzheimers Dement
December 2024
Waisman Center, University of Wisconsin-Madison, Madison, WI, USA.
Background: The triplication of the chromosome containing the gene for APP production conveys a very high risk for people with Down syndrome to develop Alzheimer's disease by their fifth decade of life.
Method: The Alzheimer's Biomarker Consortium - Down Syndrome study has tracked the trajectory of PET-measured amyloid and tau burden in the brains of individuals with Down Syndrome (>25 yrs of age) to carefully characterize their relationship with AD-related cognitive decline.
Result: Compared to sporadic AD in the neurotypical population, there is a carefully characterized accelerated time course between the emergence of these neuropathologies and the presentation of MCI and clinical dementia in the Down syndrome population.
Alzheimer's Imaging Consortium.
Alzheimers Dement
December 2024
Department of Medical Physics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI, USA.
Background: Trisomy 21 in Down syndrome (DS) is associated with an earlier accumulation of beta-amyloid (Aß) plaques and a higher rate of Alzheimer's Disease due to the triplication of the amyloid precursor protein gene. In this study we compare accumulation rates of Aß measured with [C-11]PiB PET between large longitudinal cohorts of DS and neurotypical (NT) participants at a single site.
Methods: Participants imaged at the University of Wisconsin with =2 PiB scans and =2 years between scans were included in this study.
Technology and Dementia Preconference.
Alzheimers Dement
December 2024
Cumulus Neuroscience, Dublin, Ireland.
Background: Current tools for Alzheimer's disease screening and staging used in clinical research (e.g. ACE-3, ADAS-Cog) require substantial face-to-face time with trained professionals, and may be affected by subjectivity, "white coat syndrome" and other biases.
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