AI Article Synopsis
- The text discusses a method for efficiently deracemizing phosphonic ester-substituted 3,4-dihydropyrimidin-2-one (DHPM) compounds.
- This one-pot process involves first oxidizing the compound to eliminate the original stereocenter and then performing asymmetric transfer hydrogenation to create a new chiral center.
- The result is a variety of optically active phosphonate substituted DHPMs with enantiomeric excess (ee) values reaching up to 96%.
Article Abstract
An efficient redox deracemization of the phosphonic ester substituted 3,4-dihydropyrimidin-2-one (DHPM) derivatives is described. The one-pot deracemization strategy consisted of the oxidization to destroy the stereocenter center and the following asymmetric transfer hydrogenation to regenerate the chiral carbon center with the vicinal phosphonic ester group, providing a series of optically active phosphonate substituted DHPMs with up to 96% ee.
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| http://dx.doi.org/10.1039/d1ob02079j | DOI Listing |
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