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Aqueous Leaf Extract of Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers.
J Med Food
January 2025
Department of Biomedical sciences, Oklahoma State University Centre for Health and Science, Oklahoma, USA.
The effect of the aqueous extract of (AAI) on gentamicin (GEN)-induced kidney injury was investigated. The study involves 20 adult male Wistar rats (housed in four separate plastic cages) such that graded dosages of AAI were administered to the experimental group for 14 days per oral (PO) before exposure to GEN toxicity (100 mg/kg) for 1 week. At the end of the study, comparisons of some markers of renal functions, antioxidant status, and inflammatory and apoptotic markers were made between the control, GEN, and AAI-pretreated groups at < .
View Article and Find Full Text PDFReconstruction of bone defects around the ankle with retrograde gentamicin-coated tibial intramedullary nail (ETN PROtect™) for tibiotalocalcaneal arthrodesis: a case series.
Eur J Orthop Surg Traumatol
October 2024
Limb of Lengthening and Reconstruction Unit, Clínica Imbanaco Grupo QuirónSalud, Carrera 38A #5ª-100, Tower A, Office 803, Cali, Colombia.
Article Synopsis
- The study aimed to evaluate the effectiveness of a gentamicin-coated tibial nail (PROtect™) in patients needing tibiotalocalcaneal arthrodesis due to tibial defects.
- It involved a review of seven male patients treated between January 2018 and December 2023, focusing on fracture healing, complications, and quality of life outcomes.
- Results showed that most patients achieved fracture union, though a few experienced complications; overall, PROtect™ was deemed a promising option for enhancing bone healing and reducing infection risks in complex cases.
Detection and characterization of multidrug resistant Escherichia coli carrying virulence gene isolated from broilers in Bangladesh.
Vet Med Sci
November 2024
Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Chattogram Veterinary and Animal Sciences University, Chattogram, Bangladesh.
Background: The emergence and dissemination of multidrug resistant (MDR) bacteria pose a severe threat to public health by limiting clinical treatment and prophylactic options.
Objectives: This study investigates the prevalence of Escherichia coli in broilers, their phenotypic antimicrobial resistance (AMR) profiles and the presence of virulence-associated genes (VAGs) and antimicrobial resistance genes (ARGs) using polymerase chain reaction (PCR).
Materials And Methods: A total of 216 pooled cloacal samples were collected from 1080 broilers across six districts of Bangladesh.
Variability in Profiles and Prevalences of Gram-Negative Bacteria in Urinary Tract Infections: A Population-Based Analysis.
J Clin Med
September 2024
Department of Urology, University Hospital Southampton NHS Trust, Southampton SO16 6YD, UK.
Article Synopsis
- There is a global rise in antimicrobial resistance (AMR) primarily attributed to the overuse and misuse of antibiotics, which poses challenges for healthcare and patient treatment, especially in urinary tract infections (UTIs) caused by gram-negative bacteria (GNB).
- A comprehensive analysis of over 650,000 urine cultures from a Southern England hospital over eight years revealed that Nitrofurantoin showed better effectiveness across all age groups compared to other antibiotics like ampicillin/amoxicillin and trimethoprim, which had poor resistance profiles.
- The study indicated that males and individuals over 60 are at a higher risk of developing AMR, necessitating tailored antibiotic use to improve treatment outcomes in various subpopulations.
Prophylactic absorbable antibiotic beads for prepectoral implant-based breast reconstruction: A single institution early experience.
J Plast Reconstr Aesthet Surg
September 2024
Division of Plastic Surgery, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address:
Infection after implant-based breast reconstruction remains challenging, with infection rates up to 24%. Best clinical practice indicates prophylactic oral antibiotics are ineffective at preventing infection. Absorbable antibiotic beads have been routinely used in other surgical subspecialties such as orthopedic and vascular procedures for continuous local antibiotic delivery to the surgical site when implants are placed.
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