The authors have found that a picture in Figure 6C is needed to be corrected. Reference: SunYu Chen, JianKun Wang, Chao Cai, Xiaoyan Xie. N-myc Downstream-Regulated Gene 2 (NDRG2) Promotes Bone Morphogenetic Protein 2 (BMP2)-Induced Osteoblastic Differentiation and Calcification by Janus Kinase 3 (JAK3)/Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway. Med Sci Monit 2020; 26:e918541. DOI: 10.12659/MSM.918541.
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| http://dx.doi.org/10.12659/MSM.935672 | DOI Listing |
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Unraveling the protein kinase C/NDRG1 signaling network in breast cancer.
Cell Biosci
December 2024
Department of Biological and Environmental Sciences and Technologies (DiSTeBA), University of Salento, Lecce, Italy.
N-myc downstream-regulated gene 1 (NDRG1) is a member of the NDRG family of intracellular proteins and plays a central role in a wide range of biological processes including stress response, differentiation, and metabolism. The overexpression of NDRG1 is an indicator of poor prognosis in various types of cancer. Here, we found that NDRG1 is an independent prognostic marker of poor outcome in breast cancer (BC).
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Arkh Patol
December 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov, Moscow, Russia.
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November 2024
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Clinically approved iron chelators, originally designed to address iron overload disorders, have emerged as potential anticancer agents. Deferasirox (Def), a tridentate iron chelator, has demonstrated antiproliferative effects in cancer. : This study aims to elucidate the mechanism of action of Def and its impact on non-small cell lung carcinoma (NSCLC).
View Article and Find Full Text PDFNDRG1 upregulation by ubiquitin proteasome system dysfunction aggravates neurodegeneration.
Mol Brain
October 2024
Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8503, Japan.
Protein turnover is crucial for cell survival, and the impairment of proteostasis leads to cell death. Aging is associated with a decline in proteostasis, as the progressive accumulation of damaged proteins is a hallmark of age-related disorders such as neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS). We previously discovered that the declining function of the ubiquitin-proteasome system (UPS) in motor neurons contributes to sporadic ALS pathologies, such as progressive motor neuron loss, protein accumulation, and glial activation.
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