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Are CRISPR Screens Providing the Next Generation of Therapeutic Targets? | LitMetric

AI Article Synopsis

  • - CRISPR screens and genetic profiling of cell lines are helping researchers pinpoint vulnerabilities in cancer, leading to promising drug discovery programs.
  • - While many target-specific drugs are in clinical testing, loss-of-function studies are still developing, with challenges like genetic redundancy and limitations of current cell line models.
  • - Initiatives like the Cancer Dependency Map are expected to significantly advance the identification of oncology therapeutic targets in the coming years.

Article Abstract

CRISPR screens combined with molecular and genetic profiling of large panels of cell lines are helping to systematically identify cancer vulnerabilities. These large-scale screens, together with focused and isogenic cell line screens, have identified a growing number of promising targets and led directly to numerous target-specific drug discovery programs, several of which have reached clinical testing. However, systematic loss-of-function studies are still in their early stages. Genetic redundancy, the limitation of cell line models for many cancer types, and the difficulty of conducting complex and screens remain opportunities for discovery. We expect that over the next few years, efforts like the Cancer Dependency Map along with more focused screens will play a significant role in the creation of a roadmap of oncology therapeutic targets.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10078623PMC
http://dx.doi.org/10.1158/0008-5472.CAN-21-1784DOI Listing

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