Antioxidant and cytotoxicity activities of δ-tocotrienol from the seeds of .

Chemical investigation of P. Beauv fruits led to the isolation of a new -tocotrienol, 3-hydroxy-δ-tocotrienol () together with eight known compounds (-). Compound ( was allylated () and prenylated ( and ) to give three new semi-synthesized derivatives which were fully characterized as: 6--allyl-3-hydroxy-δ-tocotrienol (), 6--prenyl-3-hydroxy-δ-tocotrienol () and 6-,5-C-diprenyl-3-hydroxy-δ-tocotrienol (). The structures of compounds were established using comprehensive spectroscopic analysis including UV, MS, 1 D NMR, 2 D NMR and by comparison with the corresponding literature data. Compound () and its semi-synthetic derivatives () were tested for their antioxydant activity using DPPH radical scavenging assay and also for their cytotoxicity using human cervix carcinoma KB-3-1 cell lines. The results showed that compound ( exhibited antioxidant activity with an IC value of 0.25 M compared to the reference control trolox (26 M); and good cytotoxic activity with IC values of 97 M compared to the reference (+)-griseofulvin (IC between17-21 M).