Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648937 | PMC |
| http://dx.doi.org/10.1590/0004-282X-ANP-2021-0297 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Retinal Examination in Neurodegenerative Diseases of the Brain.
Alzheimers Dement
December 2024
D‐ NO Visual Therapy Center, Istanbul, Turkey; Uskudar University, İstanbul, Turkey
Background: Alzheimer's Disease (AD) is a chronic neurodegenerative disease characterized by loss of memory and cognitive decline associated with an increase in ß‐amyloid (Aß) plaque deposition, neurofibrillary tangle formation (NFT) and inflammation. Fundus Autofluorescein (FAF) can detect lipofuscin secreted by misfolded plaques during the neurodegeneration process. And Optical Scanning Tomography ( OCT ) is able to find out the retinal layers of the accumulation ( inner retinal layers in AD ).
View Article and Find Full Text PDFRetinal imaging in polarized light of two different protein deposit types found in the retina in different neurodegeneration diseases (NDDs).
Alzheimers Dement
December 2024
Vancouver General Hospital, Vancouver, BC, Canada
Background: Amyloid and alpha synuclein proteins are brain biomarkers of different neurodegenerative diseases, many years before symptoms. We have shown that imaging dye‐free with polarized light makes retinal amyloid deposits visible as a biomarker, in the brain, of amyloid and Alzheimer's disease (AD) severity. Here, we extend to presumed retinal alpha synuclein deposits in those with brain pathology consistent with alpha synuclein.
View Article and Find Full Text PDFRetinal and brain imaging modalities for AD detection and monitoring.
Alzheimers Dement
December 2024
Australian Alzheimer's Research Foundation, Perth, Western Australia, Australia
Background: As an extension of the central nervous system (CNS), the retina shares many similarities with the brain and can manifest signs of various neurological diseases, including Alzheimer’s disease (AD). This study investigates the spectral features of the retina to develop a classification model for the differentiation of individuals with elevated brain amyloid levels.
Method: Participants (n=66) with varying brain Aβ levels, as determined by brain imaging, were non‐invasively imaged using a hyperspectral retinal camera at wavelengths of 450 to 905 nm.
Retinal perivascular amyloid imaging in relationship to MRI neuroimaging abnormalities and cognitive impairment.
Alzheimers Dement
December 2024
Department of Neurosurgery, Maxine Dunitz Neurosurgical Research Institute, Cedars‐Sinai Medical Center, Los Angeles, CA, USA
Background: Scanning laser ophthalmoscopy (SLO) visualizes two important markers of cognitive dysfunction in the retina: vascular changes and amyloid plaque (AP) deposition. The relationship between retinal arteriolar versus venular changes and perivascular amyloid deposition across the continuum of neurodegeneration is imperfectly understood. We investigate the retinal perivascular AP distribution in relationship to cognitive and neuroimaging measures in a cohort of cognitively normal and impaired individuals.
View Article and Find Full Text PDFRelationships Between Retinal Amyloid Imaging and Amyloid PET in the A4 Trial.
Alzheimers Dement
December 2024
Center for Alzheimer’s Research and Treatment, Brigham and Women’s Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Background: Alterations to the retina manifest in patients diagnosed with neurodegenerative diseases such as Alzheimer’s disease (AD). Retinal imaging techniques open the possibility for non‐invasive evaluation of AD pathology. Clinically AD diagnosed patients exhibit retinal amyloid deposits.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!