AI Article Synopsis
- Phenolic compounds have health benefits, and their bioavailability is influenced by factors like diet, sex, and biological rhythms.
- The study investigated how the timing of grape proanthocyanidin extract (GSPE) administration affects its absorption in Fischer 344 rats on different diets.
- Results showed that the time of day, type of diet, and the sex of the rats significantly impacted the bioavailability of these compounds.
Article Abstract
Scope: Phenolic compounds are bioactive molecules that are associated with several health benefits. Metabolization and absorption are the main determinants of their bioavailability and bioactivity. Thus, the study of the factors that modulate these processes, such as sex or diet is essential. Recently, it has been shown that biological rhythms may also play a key role. Hence, the aim of this study is to evaluate if the bioavailability of a grape proanthocyanidin extract (GSPE) is affected by the administration time in an animal model of metabolic syndrome (MetS).
Methods And Results: Female and male Fischer 344 rats are fed either a standard or a cafeteria diet (CAF) for 9 weeks, and an oral dose of GSPE (25 mg kg ) is daily administered either at 8:00 am (zeitgeber time (ZT)-0) or at 8:00 pm (ZT-12) during the last 4 weeks. Plasma phenolic compounds are then quantified by liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS/MS). Phase-II and gut microbiota-derived phenolic metabolites are affected by ZT in all conditions or only in obese rats, respectively. CAF feeding affected the bioavailability of phenolic acids and free flavan-3-ols. Differences due to sex are also observed.
Conclusion: These findings demonstrate that ZT, diet, and sex are key factors influencing phenolic compounds bioavailability.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/mnfr.202100552 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Antioxidant and anti-inflammatory function of walnut green husk aqueous extract (WNGH-AE) on human hepatocellular carcinoma cells (HepG2) treated with t-BHP.
PLoS One
January 2025
Institute of Natural Antioxidants and Anti-Inflammation, Dali University, Dali, Yunnan, China.
Oxidative damage, oxidative inflammation, and a range of downstream diseases represent significant threats to human health. The application of natural antioxidants and anti-inflammatory agents can help prevent and mitigate these associated diseases. In this study, we aimed to investigate the effectiveness of walnut green husk (WNGH) as an antioxidant and anti-inflammatory agent in an in vitro setting.
View Article and Find Full Text PDFNew α-Glucosidase Inhibitors from Vietnamese Garcinia schomburgkiana Fruits.
Chem Biodivers
January 2025
Saigon University, Institute of Environment-Energy Technology, 273 An Duong Vuong Street, Ho Chi Minh City, Ho Chi Minh City, VIET NAM.
The chemical investigation of the fruits of Garcinia schomburgkiana growing in Vietnam led to the isolation of a new anofinic acid derivative, 5-hydroxy-8-methoxyanofinic acid (1), a new xanthone, xanthoschome C (2), and a known synthetic phenolic analogue, 4-(2-hydroxybenzyl)-2-(4-hydroxybenzyl) phenol (3), along with seven known xanthones (4-10). The structures of all isolated compounds were determined using spectroscopic techniques (NMR and MS), in conjunction with comparison to existing literature data. All isolated compounds were assessed for their α-glucosidase inhibitory activity and showed significant inhibition, with IC50 values ranging from 12.
View Article and Find Full Text PDF[Allelopathy: chemical communication between plants].
Biol Aujourdhui
January 2025
Université Paris-Saclay, INRAE, AgroParisTech, Institut Jean-Pierre Bourgin for Plant Sciences (IJPB), 78000 Versailles, France.
Today, weed control in agricultural systems is largely based on the use of synthetic pesticides. However, the use of these compounds is increasingly controversial among farmers and consumers, who point to their harmful properties for human health and the environment. In this context, the development of eco-friendly agricultural approaches and practices is becoming essential, and allelopathy represents a promising solution.
View Article and Find Full Text PDFProperties of encapsulated raspberry powder and its efficacy for improving the color stability and amino acid composition of pastırma cemen pastes with different pH during long term cold-storage.
J Food Sci Technol
February 2025
DÖHLER Food, İstanbul, Turkey.
Unlabelled: In this study, the changes in the physicochemical properties, color stability, and amino acid composition of cemen paste (CP) produced by adjusting to different pH levels (3.0, 4.0, 5.
View Article and Find Full Text PDFOven roasting effects on the physicochemical and chemosensory characteristics of hemp seeds ( L.).
J Food Sci Technol
February 2025
Department of GreenBio Science/Food Science and Technology, Gyeongsang National University, Jinju, 52725 Republic of Korea.
Physicochemical properties and flavor characteristics of hemp seeds (HS) were analyzed by roasting temperature (140 °C, 160 °C, 180 °C) and time (initial, 3, 6, 9, 12 min). HS with roasting showed a lightness () with increasing roasting time. Total flavonoid content (TFC) decreased significantly with roasting compared to initial, and total phenolic content (TPC) tended to decrease with increasing roasting time at low temperatures (140 °C), but relatively high temperatures (160 °C and 180 °C), TPC increased significantly with increasing roasting time.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!