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Pacemaking in cardiac tissue. From IK2 to a coupled-clock system.
Physiol Rep
January 2019
Katholieke Universiteit Leuven, Leuven, Belgium.
Initially, diastolic depolarization in Purkinje fibers was explained by deactivation of gK2 in the presence of inward current. Weakness of the hypothesis was a too negative reversal potential, sensitivity to external Na ions, existence of K depletion, and fake current during hyperpolarizing clamps. The development of a sinus node preparation of almost microscopic dimensions allowing uniform voltage clamps created new possibilities.
View Article and Find Full Text PDFConduction in cardiac tissue. Historical reflections.
Physiol Rep
January 2019
Katholieke Universiteit Leuven, Leuven, Belgium.
Two hypotheses have been proposed to explain propagation of the action potential in heart. According to the gap junction hypothesis local short-circuit currents pass from the proximal depolarized cell to the distal inactive cell via gap junctions and are responsible for the depolarization of the distal cell. In the ephapse hypothesis the depolarization of the proximal cell generates an electrical field in the narrow cleft between cells resulting in depolarization beyond threshold of the distal cell.
View Article and Find Full Text PDFFrom Bernstein's rheotome to Neher-Sakmann's patch electrode. The action potential.
Physiol Rep
January 2019
Katholieke Universiteit Leuven, Leuven, Belgium.
The aim of this review was to provide an overview of the most important stages in the development of cellular electrophysiology. The period covered starts with Bernstein's formulation of the membrane hypothesis and the measurement of the nerve and muscle action potential. Technical innovations make discoveries possible.
View Article and Find Full Text PDFEditorial commentary: This sodium current may be late, but it is important.
Trends Cardiovasc Med
February 2016
Faculty of Medicine, K.U.L., Leuven, Belgium.
To the Editor--Propranolol, a β-adrenoreceptor blocker, prevents arrhythmias also by its sodium channel blocking effect.
Heart Rhythm
March 2014
Centre for Cardiovascular Sciences University of Birmingham Birmingham, United Kingdom; University Hospital Muenster, Germany.
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