AI Article Synopsis
- The study introduces a new approach that combines enzymes and polar organometallic chemistry in one reaction process.
- It demonstrates the efficient oxidation of secondary alcohols using laccase and TEMPO, followed by rapid reaction (within 3 seconds) with polar organometallic reagents to form ketones.
- This method enables the selective and effective synthesis of tertiary alcohols with high yields, achieving conversion rates of up to 96% under mild conditions.
Article Abstract
The one-pot/two-step combination of enzymes and polar organometallic chemistry in aqueous media is for the first time presented as a proof-of-concept study. The unprecedented combination of the catalytic oxidation of secondary alcohols by the system laccase/TEMPO with the ultrafast addition (3 s reaction time) of polar organometallic reagents (RLi/RMgX) to the formed ketones, run under air at room temperature, allows the straightforward and chemoselective synthesis of tertiary alcohols with broad substrate scope and excellent conversions (up to 96%).
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| http://dx.doi.org/10.1039/d1cc06460f | DOI Listing |
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