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Objective: The objective of this study was to evaluate the thyroid glands' radiation dose and the risk of thyroid cancer induction from head or neck computed tomography (CT) examinations.
Methods: In a prospective study, we evaluated all participants of all ages and sex referred for Head or Neck CT Scan at the University College Hospital, Ibadan and Me Cure Healthcare Limited, Ibadan, Oyo State, Nigeria. Thyroid radiation dose was estimated with impact scan calculator, and real-time dose measurement with thermoluminescent badge dosimeters (TLDs). Data were analysed and P < 0.05 was considered statistically significant.
Results: One hundred and sixty-three participants (128 adults and 35 children) participated in the study. In most participants (74%), the tube voltage was 120 kVp. The estimated median thyroid gland dose by the imPACT scan calculator was 4.95 mGy (range = 1.20-30.0 mGy) and 4.40 mGy (range = 3.0-5.10 mGy), while the real-time dose measured by the TLD was 4.79 mGy (range = 1.73-96.7 mGy) and 2.33 mGy (range = 1.20-3.73 mGy) at Centre A and B, respectively. The estimated median thyroid cancer risk was 2.88 × 10 (maximum range of 52 × 10) at centre A and a median value of 3.20 × 10 with a cancer risk estimate that may reach 17.9 × 10 recorded at centre B, compared to a cumulative thyroid cancer risk of 0.12 × 10 among the general Nigerian population.
Conclusions: Scanner specifications and technique may significantly contribute to variations seen in thyroid radiation doses. There may be a need to optimise centre protocols and apply dose reference levels for head and neck CT examinations to reduce thyroid cancer risk in Nigeria.
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http://dx.doi.org/10.4103/npmj.npmj_611_21 | DOI Listing |
Ann Ital Chir
December 2024
Department of General Surgery, Faculty of Medicine, Dicle University, 21280 Diyarbakır, Türkiye.
Aim: In early-stage breast cancer, the axillary lymph nodes play a crucial role in determining the prognosis of the disease. The rate of lymph node involvement might be a more valuable prognostic factor than the number of positive lymph nodes. Therefore, we aimed to evaluate whether the lymph node ratio (LNR) is a superior prognostic indicator compared to the pathologic lymph node count in early-stage disease.
View Article and Find Full Text PDFAnn Ital Chir
December 2024
Department of Gastrointestinal Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, 830000 Urumqi, Xinjiang, China.
Aim: Colorectal cancer (CRC) primarily arises from a combination of genetic, environmental, and dietary factors. Compared to traditional open surgery, minimally invasive laparoscopic surgery offers several advantages in managing CRC. This study investigates the factors influencing dynamic intestinal obstruction following laparoscopic colorectal radical surgery.
View Article and Find Full Text PDFDiabetes Obes Metab
December 2024
The Center for Health AI and Synthesis of Evidence (CHASE), University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Aim: To comprehensively evaluate the benefits and risks of glucagon-like peptide-1 receptor agonists (GLP-1RA), dipeptidyl peptidase 4 inhibitors (DPP4i), and sodium-glucose cotransporter 2 inhibitors (SGLT2i).
Materials And Methods: A systematic search of PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to November 2023 to identify randomized cardiovascular and kidney outcome trials that enrolled adults with type 2 diabetes, heart failure, or chronic kidney disease and compared DPP4i, GLP-1RAs, or SGLT2i to placebo. Twenty-one outcomes (e.
Front Oncol
December 2024
Gynecologic Oncology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Uterine carcinosarcoma (UCS), or malignant mixed Müllerian tumor, is a cancer that include both carcinomatous and sarcomatous components, resembling endometrial carcinoma. A 55-year-old woman was admitted to the hospital with postmenopausal vaginal bleeding. Gross examination of the specimen revealed brittle tissue in the fundus and the left wall of the endometrium.
View Article and Find Full Text PDFFront Oncol
December 2024
Department of Urology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva, Israel.
Introduction: The prostate biopsy (PB) results should be concordant with prostatectomy histopathology to avoid overestimating or underestimating the disease, leading to inappropriate or undertreatment of prostate cancer (PCa) patients. Since the introduction of multiparametric Magnetic Resonance Imaging (mpMRI) in the diagnostic pathway of PCa, most studies have shown that MRI/Ultrasound fusion-guided (MRI-fusion) PB improves concordance with histopathology of radical prostatectomy specimens. This study aimed to evaluate the improvement in concordance of prostatectomy specimens with PB histopathology obtained using the MRI-fusion approach compared with the 12-core TRUS-Bx and to identify the variables influencing this.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!