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Airspace closures due to reentering space objects.
Sci Rep
January 2025
Department of Political Science, University of British Columbia, Vancouver, BC, Canada.
Uncontrolled reentries of space objects create a collision risk with aircraft in flight. While the probability of a strike is low, the consequences could be catastrophic. Moreover, the risk is rising due to increases in both reentries and flights.
View Article and Find Full Text PDFPerceived financial hardship and sleep in an adult population-based cohort: The mediating role of psychosocial and lifestyle-related factors.
Sleep Health
January 2025
Unit of Population Epidemiology, Division of Primary Care, Geneva University Hospitals, Geneva, Switzerland; Department of Health and Community Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland; School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Background: Social inequalities in sleep have been reported, but there is less research on the mechanisms underlying this association. This study investigates the relationship between financial hardship and sleep within the general adult population, focusing on the mediating effects of psychosocial and lifestyle-related factors.
Methods: We used data from the Specchio cohort, a population-based study in Geneva, Switzerland, initiated in December 2020.
Computational Nuclear Oncology Toward Precision Radiopharmaceutical Therapies: Ethical, Regulatory, and Socioeconomic Dimensions of Theranostic Digital Twins.
J Nucl Med
January 2025
United Theranostics, Bethesda, Maryland.
Computational nuclear oncology for precision radiopharmaceutical therapy (RPT) is a new frontier for theranostic treatment personalization. A key strategy relies on the possibility to incorporate clinical, biomarker, image-based, and dosimetric information in theranostic digital twins (TDTs) of patients to move beyond a one-size-fits-all approach. The TDT framework enables treatment optimization by real-time monitoring of the real-world system, simulation of different treatment scenarios, and prediction of resulting treatment outcomes, as well as facilitating collaboration and knowledge sharing among health care professionals adopting a harmonized TDT.
View Article and Find Full Text PDFInsilico and Invivo protective effect of biochanin-A mitigating doxorubicin- induced cognitive deficits and neuroinflammation: Insights to the role of p-Tau and miR-132.
Neurotoxicology
January 2025
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Ain Shams University, Cairo, 11566, Egypt. Electronic address:
Doxorubicin (DOX)-induced chemobrain has been reported in several studies. Its main culprit is the induction of massive amounts of reactive oxygen species (ROS), hence triggering damage to brain tissues and thus leading to neuroinflammation. Biochanin A (BIO-A) is known to be an antioxidant, anti-inflammatory, and neuroprotective agent.
View Article and Find Full Text PDFExposure experiments and machine learning revealed that personal care products can significantly increase transdermal exposure of SVOCs from the environment.
J Hazard Mater
January 2025
Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
We investigated the impacts of personal care products (PCPs) on dermal exposure to semi-volatile organic compounds (SVOCs), including phthalates, organophosphate esters, polycyclic aromatic hydrocarbons (PAHs), ultraviolet filters, and p-phenylenediamines, through an experiment from volunteers, explored the impact mechanisms of PCP ingredients on dermal exposure, and predicted the PCP effects on SVOC concentrations in human serum using machine learning. After applying PCPs, namely lotion, baby oil, sunscreen, and blemish balm, the dermal adsorption of SVOCs increased significantly by 1.63 ± 0.
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