A novel efficient method to generate spiro furan-3(2)-imine derivatives is established by the reaction between the ,-unsaturated ketones and aniline derivatives. The reaction involves 1,4- addition of aniline followed by the subsequent intramolecular cyclization mediated by tertiary alcohol to produce the furan-3(2)-imine. All the synthesized compounds are characterized using nuclear magnetic resonance and high-resolution mass spectrometry (HRMS).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8611349 | PMC |
| http://dx.doi.org/10.1098/rsos.211145 | DOI Listing |
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