This review aimed to summarize the pharmacogenetic studies of the most commonly used drugs in the chemotherapy of gastrointestinal (GI) tumors: oxaliplatin, irinotecan, and fluoropyrimidines. So far, it has not been possible to develop an effective genotype-based approach for oxaliplatin. More and more evidence is emerging in favor of the fact that the choice of a dose of fluorouracil based on pharmacogenetic testing according to , can be not only effective but also cost-effective. Additional, well-planned trials of the genotype-based approach to irinotecan therapy are predicted to reduce adverse drug events in people with the genotypes and improve treatment efficacy in the rest of the patients, which might be cost-effective.
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