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Effects of missing data imputation methods on univariate blood pressure time series data analysis and forecasting with ARIMA and LSTM.
BMC Med Res Methodol
December 2024
School of Mathematical & Statistical Sciences, University of Texas Rio Grande Valley, One West University Boulevard, Brownsville, TX, 78520, USA.
Background: Missing observations within the univariate time series are common in real-life and cause analytical problems in the flow of the analysis. Imputation of missing values is an inevitable step in every incomplete univariate time series. Most of the existing studies focus on comparing the distributions of imputed data.
View Article and Find Full Text PDFAssociation between social engagement decline and cognitive function changes: mediating effect of depressive symptoms.
Aging Clin Exp Res
December 2024
Innovation Center of Nursing Research and Nursing Key Laboratory of Sichuan Province, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, 610041, PR China.
Background: Cognitive decline is a significant public health problem worldwide, but little is known about social engagement's impact on cognitive changes over time. This study aimed to explore the relationship between social engagement decline and cognitive function change in Chinese adults, and to analyze the effect of changes in depressive symptoms on this relationship.
Methods: Participants were selected from the China Health and Retirement Longitudinal Study.
Setpoint weighted PI-FOPD cascade controllers synthesis for unstable time-delayed processes satisfying prespecified safety margins.
ISA Trans
December 2024
Department of Electrical Engineering, Tungnan University, No. 152, Section 3, Peishen Rd., Shenkeng Dist., New Taipei 222, Taiwan. Electronic address:
This article introduces a novel setpoint weighted PI-FOPD (SWPI-FOPD) cascade controller with a prefilter. It further describes a four-stage design strategy that sequentially enhances tracking responses, reduces overshoot, and ensures robustness for unstable time-delayed (UTD) processes. The controller applies to integrating and non-integrating UTD processes of any order and does not necessitate model order reduction or delay approximation.
View Article and Find Full Text PDFLeachables Analysis from a Closed Connected Single-Use mAb Purification Process.
PDA J Pharm Sci Technol
December 2024
Cytiva, Bjorkgatan 30, 75323 Uppsala, Sweden.
During a closed connected single-use monoclonal antibody (mAb) purification process, samples for leachables screening were gathered from two parallel processes (using different capturing chromatography), from perfusion culture to final storage bags. These samples were prepared and analyzed using screening methods for HS-GC-MS, GC-MS, LC-QToF/ESI pos and neg, to be able to identify a broad spectrum of leachables. The identified compounds were sorted into sample points from different steps of the mAb process, compared with available extractables data mapped from the process equipment used.
View Article and Find Full Text PDFDeciphering the mineral code of urinary stones: A first look at zinc isotopes.
Environ Pollut
December 2024
Nu instruments, Wrexham Industrial Estate, 74 Clywedog Road South, Wrexham LL13 9XS, United Kingdom.
Zinc (Zn) is an essential element for all living organisms, and Zn isotopes play a key role in studying the formation of disease. Despite extensive studies on Zn isotopes in healthy and diseased human tissues, the role of Zn isotopes in urinary stones remains unexplored. This study investigates Zn isotopes in 37 urinary stones using multi-collector inductively coupled plasma mass spectrometry.
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