AI Article Synopsis
- - The split-virus vaccine is a key defense against influenza but isn't fully effective; research has shown that Benifuuki green tea can enhance its immune response.
- - A compound called EGCG3"Me from the tea boosts the vaccine's ability to increase hemagglutination inhibition titers, suggesting a stronger immune reaction.
- - Increased expression of Toll-like receptor 5 (TLR5) in immune cells, linked to important immune mediators, indicates that EGCG3"Me helps improve the body’s immune response to the vaccine.
Article Abstract
Split-virus vaccine serves as a major countermeasure against influenza virus, but its effectiveness and protective action are not complete. We previously demonstrated the effect of Benifuuki, a green tea cultivar in Japan, on enhancing the split-virus vaccine-elicited immune response. However, little is known about the detail mechanisms. Here, we show that EGCG3"Me intake significantly potentiated the vaccine-elicited hemagglutination inhibition titer increase. Flow cytometry analysis revealed the increased Toll-like receptor 5 (TLR5) expression after EGCG3"Me treatment in lamina propria dendritic cells (LPDCs) and macrophages, which play crucial roles in the humoral immune system. TLR5 expression correlated with the level of interleukin-6 (IL-6)/C-C chemokine type receptor 5, which are important mediators of the humoral immunity. Taken together, In vivo and ex vivo studies showed that EGCG3"Me potentiated the split-virus vaccine-elicited immune response accompanied with the upregulation of TLR5 in intestine and splenocyte macrophages.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8630126 | PMC |
| http://dx.doi.org/10.1038/s41598-021-02346-4 | DOI Listing |
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