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| http://dx.doi.org/10.1038/s41421-021-00336-4 | DOI Listing |
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Giant cell arteritis: update on pathogenesis and clinical implications.
Curr Opin Rheumatol
January 2025
Centre for Arthritis and Musculoskeletal Health, University of Aberdeen, Aberdeen, UK.
Purpose Of Review: Giant cell arteritis (GCA) is an age-related autoimmune disease with a complex pathogenesis that involves several pathogenic mechanisms. This review provides recent critical insights into novel aspects of GCA pathogenesis.
Recent Findings: The use of novel approaches, including multiomic techniques, has uncovered notable findings that broaden the understanding of GCA pathogenesis.
Phase separation of planetary ices explains nondipolar magnetic fields of Uranus and Neptune.
Proc Natl Acad Sci U S A
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Department of Earth and Planetary Science, University of California, Berkeley, CA 94720.
The Voyager spacecraft discovered that the ice giants Uranus and Neptune have nondipolar magnetic fields, defying expectations that a thick interior layer of planetary ices would generate strong dipolar fields. Stanley and Bloxham showed that nondipolar fields emerge if the magnetic field is only generated in a thin outer layer. However, the origin and composition of this dynamo active layer has so far remained elusive.
View Article and Find Full Text PDFA giant planet transiting a 3-Myr protostar with a misaligned disk.
Nature
November 2024
Department of Physics and Kavli Institute for Astrophysics and Space Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Astronomers have found more than a dozen planets transiting stars that are 10-40 million years old, but younger transiting planets have remained elusive. The lack of such discoveries may be because planets have not fully formed at this age or because our view is blocked by the protoplanetary disk. However, we now know that many outer disks are warped or broken; provided the inner disk is depleted, transiting planets may thus be visible.
View Article and Find Full Text PDFMitochondria-giant lipid droplet proximity and autophagy suppression in nitrogen-depleted oleaginous yeast Lipomyces starkeyi cells.
J Biochem
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Laboratory of Mitochondrial Dynamics, Graduate School of Frontier Biosciences, Osaka University, 1-3 Yamadaoka, Suita, Osaka 565-0871, Japan.
Balancing energy production and storage is a fundamental process critical for cellular homeostasis in most eukaryotes that relies on the intimate interplay between mitochondria and lipid droplets. In the oleaginous yeast Lipomyces starkeyi under nitrogen starvation, lipid droplet forms a single giant spherical structure that is easily visible under a light microscope. Currently, how mitochondria behave in L.
View Article and Find Full Text PDFThe senolytic drug ABT-263 accelerates ovarian aging in older female mice.
Sci Rep
October 2024
The Center for Reproductive Medicine, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China.
Article Synopsis
- * Fourteen 16-month-old mice received either ABT-263 or a control vehicle for two weeks, while younger mice were used for comparison.
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