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Surface enzyme-polymerization endows Janus hydrogel tough adhesion and regenerative repair in penetrating orocutaneous fistulas.
Nat Commun
December 2024
Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain-Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Penetrating orocutaneous or oropharyngeal fistulas (POFs), severe complications following unsuccessful oral or oropharyngeal reconstruction, remain complex clinical challenges due to lack of supportive tissue, contamination with saliva and chewed food, and dynamic oral environment. Here, we present a Janus hydrogel adhesive (JHA) with asymmetric functions on opposite sides fabricated via a facile surface enzyme-initiated polymerization (SEIP) approach, which self-entraps surface water and blood within an in-situ formed hydrogel layer (RL) to effectively bridge biological tissues with a supporting hydrogel (SL), achieving superior wet-adhesion and seamless wound plugging. The tough SL hydrogel interlocked with RL dissipates energy to withstand external mechanical stimuli from continuous oral motions like chewing and swallowing, thus reducing stress-induced damage.
View Article and Find Full Text PDFNonadjustable state of programmable shunt valve: obstruction of middle cranial fossa arachnoid cyst-peritoneal shunt.
Chin Neurosurg J
December 2024
Department of Neurosurgery, Hebei Children's Hospital, Hebei Medical University, Shijiazhuang, Hebei, China.
Background: A nonadjustable state of the programmable shunt valve is a rare phenomenon. This case report aims to explore the cause of pressure adjustment dysfunction in a programmable shunt valve in a middle cranial fossa arachnoid cyst-peritoneal shunt patient and to underscore this dysfunction as an indicator of shunt valve obstruction.
Case Presentation: A child with a ruptured giant arachnoid cyst in the left middle cranial fossa presented with acute intracranial hypertension following head trauma.
Tough and self-adhesive zwitterionic hydrogels with mechano-responsive release of bFGF for tympanic membrane repair.
Mater Today Bio
October 2024
Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo, 315040, Zhejiang, PR China.
The tympanic membrane (TM) is constantly in a state of vibrating. However, there is currently a lack of drug-delivery scaffolds suitable for the dynamic environment of TM perforation. In this study, a mechano-responsive tough hydrogel was developed.
View Article and Find Full Text PDFThe Role of Social Support in Concussion Rehabilitation: A Prospective Mixed Methods Study of Canadian University Athletes' Return to Sport.
J Sport Rehabil
October 2024
Department of Kinesiology and Physical Education, University of Lethbridge, Lethbridge, AB, Canada.
Context: Social support is an important consideration during athletes' rehabilitation following a concussion. Yet, its influence during the return-to-sport (RTS) strategy has been underexplored.
Design: Concussed athletes' experiences with social support during RTS were explored prospectively using an explanatory sequential mixed methods design.
Tension-Free Weight-Bearing Model of Steroid-Induced Osteonecrosis of Femoral Head in Rats.
J Vis Exp
September 2024
Beijing Key Lab of Immune-Mediated Inflammatory Diseases, China-Japan Friendship Hospital; Department of Orthopedic and Joint Surgery, China-Japan Friendship Hospital;
Article Synopsis
- Rats are quadrupedal animals, unlike bipedal humans, and their hips endure different biomechanical pressures that can impact research models for human hip issues.
- Some studies have attempted to simulate human hip pressure in rats by applying weights, but conventional methods can harm the rats by causing suffocation or injury.
- Our research utilized elastic therapeutic tape for safe weight-bearing immobilization, revealing that this approach worsened femoral head necrosis progression compared to traditional models.
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