Nine new compounds, including five natural rarely-occurring 2, 3-dihydro-1H-indene derivatives named diaporindenes E-I (1-5), and four new benzophenone analogues named tenellones J-M (6-9) were isolated from the deep-sea sediment-derived fungus Phomopsis lithocarpus FS508. All the structures for these new compounds were fully characterized on the basis of spectroscopic data, NMR spectra, and ECD calculation and single-crystal X-ray diffraction analysis. The potential anti-tumor activities of compounds 1-9 against four tumor cell lines SF-268, MCF-7, HepG-2, and A549 were evaluated using the SRB method. Compound 7 exhibited cytotoxic activity against the SF-268 cell line with an IC value of 11.36 μmol·L.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S1875-5364(21)60095-X | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Mycovirome of Diaporthe helianthi and D. gulyae, causal agents of Phomopsis stem canker of sunflower (Helianthus annuus L.).
Virus Res
January 2025
USDA-ARS, Application Technology Research Unit, Wooster, OH, United States. Electronic address:
Diaporthe gulyae and D. helianthi cause Phomopsis stem canker, which is a yield-limiting fungal disease of sunflower (Helianthus annuus L.) in the United States.
View Article and Find Full Text PDFAn unusual family of bifunctional terpene synthases has been discovered in which both catalytic domains - a prenyltransferase and a cyclase - are connected by a long, flexible linker. These enzymes are unique to fungi and catalyze the first committed steps in the biosynthesis of complex terpenoid natural products: the prenyltransferase assembles 5-carbon precursors to form C geranylgeranyl diphosphate (GGPP), and the cyclase converts GGPP into a polycyclic hydrocarbon product. Weak domain-domain interactions as well as linker flexibility render these enzymes refractory to crystallization and challenge their visualization by cryo-EM.
View Article and Find Full Text PDFFirst report of causing Phomopsis stem canker on sunflower ( L.) in Minnesota.
Plant Dis
December 2024
USDA-ARS Plains Area, Edward T. Schafer Agricultural Research Center, Sunflower Improvement Research Unit, Fargo, North Dakota, United States;
Cultivated sunflower (Helianthus annuus L.) is a globally important oilseed crop that is grown primarily in the Northern Great Plains region of the United States. In September 2018, sunflower stems exhibiting brown stem lesions centered on the leaf axils and accompanied by pith degradation, consistent with symptoms of Phomopsis stem canker (PSC) disease, were sampled from a commercial field of approximately 520 hectares in Polk County, MN (47°50'24" N, 96.
View Article and Find Full Text PDFPreservative for High Antioxidant and Antimicrobial Activity and Low Toxicity.
Langmuir
December 2024
State Key Laboratory of Digital Medical Engineering, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China.
Article Synopsis
- There's a growing need for safe and effective preservatives for fruits and vegetables to keep them fresh longer.
- Researchers created a new preservative using nicotinated starch enhanced with cinnamic acids, which showed strong antioxidant and antimicrobial activity.
- The new starch-based preservative extended cherry tomatoes' shelf life by three days while being non-toxic to cells, showing great potential for use in food preservation.
First Report of on Soybean in Germany.
J Fungi (Basel)
November 2024
Department of Phytopathology, Institute of Phytomedicine, Faculty of Agricultural Sciences, University of Hohenheim, 70599 Stuttgart, Germany.
(anamorph: ) species are endophytes or fungal pathogens for many different plant species. Soybean () can be infected by many different species; among them, and are responsible for the most significant damages. is a species that was only recently described and has so far been found on sunflower () in Australia and an unknown host in Thailand.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!