AI Article Synopsis
- Researchers developed and tested a series of formononetin derivatives that have different benzyloxy groups attached to the 4' position of isoflavone to see how they affect blood vessels.
- The new compounds were tested for their ability to relax blood vessels using a rat model, providing insight into their potential effectiveness.
- Some compounds displayed strong vasodilative effects and also helped lower blood pressure in hypertensive rat models when given orally.
Article Abstract
A series of formononetin derivatives with substituted benzyloxy groups on the 4' position of isoflavone were designed and synthesized. Their vasodilative activities were evaluated by wire myograph system on isolated rat mesenteric arterial ring. The preliminary SAR of target compounds was thus discussed. Compounds and exhibited potent vasodilative activities against the rat mesenteric arterial rings induced contraction with K. Compounds and also showed antihypertensive effects in SHRs by oral administration.
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| http://dx.doi.org/10.1080/10286020.2021.2005588 | DOI Listing |
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