AI Article Synopsis
- Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, necessitating the identification of molecular targets to enhance patient treatment and prognosis.
- The analysis of various gene expression databases revealed five long non-coding RNAs (lncRNAs) linked to survival in GBM, and a specific regulatory pathway involving H19, hsa-miR-338-3P, and NRP1 was identified.
- High levels of NRP1 in GBM patients correlated with poor prognosis, suggesting that NRP1 could serve as an independent prognostic indicator for GBM outcomes.
Article Abstract
Glioblastoma multiforme (GBM) is the most common and also the most invasive brain cancer. GBM progression is rapid and its prognosis is poor. Therefore, finding molecular targets in GBM is a critical goal that could also play important roles in clinical diagnostics and treatments to improve patient prognosis. We jointly analyzed the GSE103227, GSE103229, and TCGA databases for differentially expressed RNA species, obtaining 52 long non-coding RNAs (lncRNAs), 31 microRNAs (miRNAs), and 186 mRNAs, which were used to build a competing endogenous RNA network. Kaplan-Meier and receiver operating characteristic (ROC) analyses revealed five survival-related lncRNAs: H19, LINC01574, LINC01614, RNF144A-AS1, and OSMR-AS1. With multiple optimization mRNAs, we found the H19-hsa-miR-338-3P-NRP1 regulatory pathway. Additionally, we noted high NRP1 expression in GBM patients, and Kaplan-Meier and ROC analyses showed that NRP1 expression was associated with GBM prognosis. Cox analysis indicated that NRP1 is an independent prognostic factor in GBM patients. In conclusion, H19 and hsa-miR-338-3P regulate NRP1 expression, and this pathway plays an important role in GBM.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8629300 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0260103 | PLOS |
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