(1) Background: Paralympic Powerlifting (PP) is a Paralympic modality that is predominantly about developing maximal force, as there are athletes who lift three times their body weight. Our objective was to evaluate the averages of the velocity for 30% and 50% of 1 Maximum Repetition (1 RM) on different amplitudes of the footprint in PP athletes; (2) Methods: The intervention happened over two weeks, with the first being devoted to the familiarization and testing of 1 RM, while in the second week, through the use of a linear Encoder, tests of velocity average (VA), velocity average propulsive (VAP), and velocity peak (VP) were carried out with loads of 30% and 50% of a maximum repetition 1 RM for 1× of the biacromial distance (BAD) 1.3 × BAD, 1.5 × BAD; (3) Results: There was a significant difference in the average velocity of 1 × BAD (1.16 ± 0.14 m/s, 1.07-1.26 IC; η2p 0.20) when compared to 1.3 × BAD (1.00 ± 0.17 m/s, 0.90-1.09 IC; η2p 0.20) over 30% of 1 RM. For the other velocity variables for 30% and 50% of 1 RM with different grip amplitudes, there were no significant differences; (4) Conclusions: In PP, the 1 × BAD footprint contributes significantly to VA at 30% of 1 RM when compared to the 1.3 × BAD and 1.5 × BAD footprints. For loading at 50% of 1 RM the VA, VAP and VP decreased when compared to 30% of 1 RM, to the extent that the VAP and VP generated with the 1.3 × BAD and 1.5 × BAD footprints were higher than those with 1 × BAD, other than for VA 50% of 1 RM, where the 1 × BAD footprint was superior to the others.
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http://dx.doi.org/10.3390/jfmk6040086 | DOI Listing |
J Med Chem
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, and Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Theodor-Stern-Kai 7, Frankfurt am Main 60596, Germany.
The leukotriene B4 receptor 2 (BLT2) is a G-protein coupled receptor, which is endogenously activated by 12()-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT). BLT2 is gaining attention as a potential therapeutic target involved in various pathologies including diabetic wound healing, ophthalmic diseases, and colitis. However, validation of BLT2 as drug target requires chemical probes and pharmacological tools which will allow for application in vivo.
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September 2024
Department of Internal and Family Medicine, Faculty of Medicine, The Hashemite University, Zarqa, Jordan.
Introduction: Common clinical problems are frequently seen in medical students. Gastroesophageal reflux disease (GERD) is increasingly seen in clinics and is taken seriously into consideration; from this point, we start discussing this disorder. The most important part is to find out the prevalence of GERD among medical students and determine the most dominant risk factors that affect the prognosis of the disease.
View Article and Find Full Text PDFEClinicalMedicine
January 2025
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Hematology, Oncology and Cancer Immunology, Berlin, Germany.
Background: The PanaMa trial aimed to compare the efficacy of 5-fluorouracil and folinic acid (FU/FA) ± panitumumab maintenance in untreated wild-type metastatic colorectal cancer (mCRC) patients.
Methods: In this final phase 2 trial analysis, adult mCRC patients responding to six cycles of FU/FA, oxaliplatin and panitumumab were randomized (1:1, open-label) to maintenance of either FU/FA + panitumumab or FU/FA alone. The primary endpoint was superiority of progression-free survival of maintenance (PFS; time from random assignment to progression/death) in favour of FU/FA + panitumumab.
Sci Rep
January 2025
Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, J5, 68159, Mannheim, Germany.
Inflammatory processes have been implicated in the pathophysiology of depression. In human studies, inflammation has been shown to act as a critical disease modifier, promoting susceptibility to depression and modulating specific endophenotypes of depression. However, there is scant documentation of how inflammatory processes are associated with neural activity in patients with depression.
View Article and Find Full Text PDFAm J Cardiol
January 2025
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address:
Transcatheter edge-to-edge repair (TEER) is an effective intervention for high-risk patients with severe symptomatic mitral regurgitation (MR), but its acute impact on left ventricular (LV) function has not been well studied using advanced echocardiographic techniques. This study investigated the immediate effects of TEER on LV volumes and functions, as well as their influence on mid-term outcomes, using high-resolution 3D transesophageal echocardiography. In 80 patients undergoing TEER for severe MR (mean age 79±8 years, 49% with primary MR), LV end-diastolic volume (LVEDV) and stroke volume significantly decreased (161±61 to 147±54 ml and 69±18 to 50±15 ml, respectively), while end-systolic volume increased (92±60 to 97±45 ml; p<0.
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