Talarodrides A-F, Nonadrides from the Antarctic Sponge-Derived Fungus sp. HDN1820200.

Six new nonadride derivatives, named talarodrides A-F (-), were isolated from the Antarctic sponge-derived fungus sp. HDN1820200. All structures including the absolute configurations were deduced by extensive spectroscopic analysis and computational ECD calculations. Compounds - share a rare caged bicyclo[4.3.1]-deca-1,6-diene with a bridgehead olefin and maleic anhydride core skeleton, while compounds and possess the first case of a naturally occurring 5/7/6 methanocyclonona[]furan skeleton. Talarodride A () and talarodride B () showed selective inhibitory effects against and with MICs of 3.13-12.5 μM.