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Ultrastructural evaluation of adverse effects on dentine formation from systemic fluoride application in an experimental mouse model.
Int Endod J
January 2025
Department of Oral Science and Translational Research, College of Dental Medicine, Nova Southeastern University, Fort Lauderdale, Florida, USA.
Article Synopsis
- This study investigates the effects of excessive fluoride on the microstructure of dentine in mice, as previous research has mostly focused on its impact on enamel.* -
- Male C57BL6/J mice were divided into four groups, receiving different fluoride concentrations in their drinking water for six weeks, after which various analyses were conducted to evaluate enamel and dentine properties.* -
- Results indicated that high fluoride exposure (50-125 ppm) led to enamel hypoplasia, reduced dentine mineral density, and changes in the structure of the dentine-pulp complex, demonstrating significant negative effects of excessive fluoride consumption.*
Mitochondrial reactive oxygen species promote mitochondrial damage in high glucose-induced dysfunction and apoptosis of human dental pulp cells.
J Dent Sci
January 2024
Department of Endodontics, Stomatological Hospital and Dental School of Tongji University, Shanghai, China.
Background/purpose: High glucose (HG)-induced aberrant proliferation, apoptosis and odontoblastic differentiation of dental pulp cells (DPCs) have been implicated in the pathogenesis of impaired diabetic pulp healing; however, the underlying mechanism remains unclear. This study aimed to investigate the role of mitochondrial reactive oxygen species (mtROS) and mitochondria in HG-induced dysfunction and apoptosis of DPCs.
Materials And Methods: Human DPCs (hDPCs) were cultured in a low-glucose, high-glucose, mannitol, and MitoTEMPO medium in vitro.
Chitin scaffolds derived from the marine demosponge stimulate the differentiation of dental pulp stem cells.
Front Bioeng Biotechnol
November 2023
Department of Conservative Dentistry with Endodontics, Wroclaw Medical University, Wroclaw, Poland.
Article Synopsis
- - The study focuses on the promising role of dental pulp stem cells (DPSCs) in tissue regeneration, particularly how they can differentiate into bone-forming cells when provided with the right scaffold conditions.
- - A 3D chitin scaffold modified with hydroxyapatite (HAp) was tested for its effects on DPSCs and a human osteoblast cell line, examining key biological responses like cell adhesion, proliferation, and differentiation.
- - Results indicated that the chitin scaffold not only supports DPSC and osteoblast cell adhesion but also promotes their growth and differentiation, highlighting its potential applications in regenerative medicine and tissue engineering.
Comparative microstructural study on the teeth of Mesozoic birds and non-avian dinosaurs.
R Soc Open Sci
May 2023
Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, 142 Xi-zhi-men-wai Street, Beijing 100044.
Although it is commonly considered that, in birds, there is a trend towards reduced dentition, teeth persisted in birds for 90 Ma and numerous macroscopic morphologies are observed. However, the extent to which the microstructure of bird teeth differs from other lineages is poorly understood. To explore the microstructural differences of the teeth of birds in comparison with closely related non-avialan dinosaurs, the enamel and dentine-related features were evaluated in four Mesozoic paravian species from the Yanliao and Jehol biotas.
View Article and Find Full Text PDFDentin defects caused by a Dspp frameshift mutation are associated with the activation of autophagy.
Sci Rep
April 2023
Department of Biologic and Materials Sciences, University of Michigan School of Dentistry, 1011 North University, Ann Arbor, MI, 48109-1078, USA.
Dentin sialophosphoprotein (DSPP) is primarily expressed by differentiated odontoblasts (dentin-forming cells), and transiently expressed by presecretory ameloblasts (enamel-forming cells). Disease-causing DSPP mutations predominantly fall into two categories: 5' mutations affecting targeting and trafficking, and 3' - 1 frameshift mutations converting the repetitive, hydrophilic, acidic C-terminal domain into a hydrophobic one. We characterized the dental phenotypes and investigated the pathological mechanisms of Dspp and Dspp mice that replicate the two categories of human DSPP mutations.
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